Cilag (Switzerland)

open_nipals: An sklearn-compatible Python package for NIPALS dimensionality reduction

Niels Schlusser, Ryan Wall, David R. Ochsenbein

Minor changes to the `setup.cfg` mirrored from the github repo.

ch (code pays fourni par la source)

open_nipals: An sklearn-compatible Python package for NIPALS dimensionality reduction

Niels Schlusser, Ryan Wall, David R. Ochsenbein

Minor changes to the `setup.cfg` mirrored from the github repo.

ch (code pays fourni par la source)

open_nipals

Niels Schlusser, David R. Ochsenbein, Ryan Wall

ch (code pays fourni par la source)

1612P Impact of FANCA, ATM, CDK12 alterations on survival in metastatic castration-resistant prostate cancer (mCRPC)

David Lorente, Ana Jambrina, Daniel Tello, Paula Casas et autres

es, fr, be, ch, de (code pays fourni par la source)

Feasibility of Indirect Treatment Comparisons Between Niraparib Plus Abiraterone Acetate and Other First-Line Poly ADP-Ribose Polymerase Inhibitor Treatment Regimens for Patients with BRCA1/2 Mutation-Positive Metastatic Castration-Resistant Prostate Cancer

Maria De Santis, Sara Martínez Breijo, Paul J. Robinson, Camille Capone et autres

INTRODUCTION: Poly(ADP-ribose) polymerase inhibitors (PARPi) are a novel option to treat patients with metastatic castration-resistant prostate cancer (mCRPC). Niraparib plus abiraterone acetate and prednisone (AAP) is indicated for BRCA1/2 mutation-positive mCRPC. Niraparib plus AAP demonstrated safety and efficacy in the phase 3 …

at, de, es, gb, fr, be, nl, ch, us, it (code pays fourni par la source)

Implications of therapy interruption on monthly migraine days and modified migraine disability assessment in patients treated with erenumab for chronic and episodic migraine: SQUARE study interim results

Andreas R. Gantenbein, Christophe Bonvin, Christian P. Kamm, Christoph Josef Schankin et autres

BACKGROUND: There are limited real-world data in Switzerland examining the impact of erenumab, a fully human IgG2 monoclonal antibody targeting the calcitonin gene-related peptide (CGRP) receptor, on migraine-related quality of life. OBJECTIVE: This 18-month interim analysis of 172 patients with episodic or …

ch (code pays fourni par la source)

Microfluidic Stress Device to Decouple the Synergistic Effect of Shear and Interfaces on Antibody Aggregation

Michael Gerlt, E Meier, Fabian Dingfelder, Dominik Zürcher et autres

Protein denaturation and aggregation resulting from the effects of interfacial stress, often enhanced by flow and shear stress, pose significant challenges in the production of therapeutic proteins and monoclonal antibodies. The influence of flow on protein stability is closely intertwined with interfacial …

ch (code pays fourni par la source)

Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes

Juan David Villada, Jadab Majhi, Valentin Lehuédé, Michelle E. Hendricks et autres

Fluorinated cyclopropanes are highly desired pharmacophores in drug discovery owing to the rigid nature of the cyclopropane ring and the beneficial effects of C-F bonds on the pharmacokinetic properties, cell permeability, and metabolic stability of drug molecules. Herein a biocatalytic strategy for …

us, ch (code pays fourni par la source)

Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes

Juan David Villada, Jadab Majhi, Valentin Lehuédé, Michelle E. Hendricks et autres

Abstract Fluorinated cyclopropanes are highly desired pharmacophores in drug discovery owing to the rigid nature of the cyclopropane ring and the beneficial effects of C−F bonds on the pharmacokinetic properties, cell permeability, and metabolic stability of drug molecules. Herein a biocatalytic strategy …

us, ch (code pays fourni par la source)

Late marginal ulcer perforation after Roux-en-Y Gastric bypass - A case report with two-step management

Nina Pfeifer, Thomas Steffen, Larissa Clea Vines, Patrick Folie

INTRODUCTION: Marginal ulcers are an acid-related complication of laparoscopic Roux-en-Y gastric bypass. Few cases of acute perforation have been described, and there are few reports on viable surgical management. This case report demonstrates a two-step surgical procedure for treating a perforated late …

ch (code pays fourni par la source)

Academic-Industrial Collaborations: Merging Paths to Thrive

Hongli Bao, Karla Bravo‐Altamirano, Zachary A. Buchan, Pablo J. Cabrera et autres

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTAcademic-Industrial Collaborations: Merging Paths to ThriveHongli BaoHongli BaoKey Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, …

cn, us, au, mx, jp, ch (code pays fourni par la source)

Better Together: Catalyzing Innovation in Organic Synthesis via Academic-Industrial Consortia

Jesús Alcázar, Edward A. Anderson, Huw M. L. Davies, Rio Febrian et autres

A t what became one of the most famous speeches in his career, in 1962, U.S. President John F. Kennedy issued a challenge to his nation to do what would be considered near impossible in the 20th century: land humans on the …

gb, us, fr, nl, ch (code pays fourni par la source)