Jesús Alcázar

CCDC 2483131: Experimental Crystal Structure Determination

Callum R John, Eric Tan, Callum S Begg, Andrew J P White et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2483130: Experimental Crystal Structure Determination

Callum R John, Eric Tan, Callum S Begg, Andrew J P White et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2483129: Experimental Crystal Structure Determination

Callum R John, Eric Tan, Callum S Begg, Andrew J P White et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

An automated platform for tailored late-stage halogenation of pharmaceuticals

Callum R John, Eric Tan, Callum S. Begg, Andrew J. P. White et autres

The diversification of lead compounds remains a crucial step in drug development, with bioactive molecules often requiring fine tuning of a range of important pharmaceutical properties. This is achieved through the synthesis of libraries of analogues with subtle modifications in functionality or …

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An automated platform for tailored late-stage halogenation of pharmaceuticals

Callum John, James A. Bull, Rebecca L. Greenaway, Peter Buijnsters et autres

This repository contains data accompanying the publication An automated platform for tailored late-stage halogenation of pharmaceuticals Isolated compound characterisation data contains the NMR, FTIR, and HRMS data for all isolated compounds reported in the accompanying publication. The directory is seperated by compound, …

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An automated platform for tailored late-stage halogenation of pharmaceuticals

Callum John, James A. Bull, Rebecca L. Greenaway, Peter Buijnsters et autres

This repository contains data accompanying the publication An automated platform for tailored late-stage halogenation of pharmaceuticals Isolated compound characterisation data contains the NMR, FTIR, and HRMS data for all isolated compounds reported in the accompanying publication. The directory is seperated by compound, …

gb, us, il, fr (code pays fourni par la source)

Nickel Electrocatalytic C(sp 3 )-C(sp 3 ) Cross-Coupling from Activated Carboxylic Acids and Amines

Bingqing Tang, Jennifer Morvan, Filippo Begal, Koen Kuijpers et autres

Carbon-carbon bond forming reactions are central to medicinal chemistry efforts. Methods which utilise abundant and structurally diverse building blocks can accelerate chemical space exploration in drug discovery. Herein, we report...

Automated Alkylation of Heteroaromatic Thioethers with Organozinc Reagents for Library Synthesis

Javier Mazuela, Paula Cervantes-Cerrada, Lucía Alcaide, Belén Chaves‐Arquero et autres

In this study, we describe the implementation of an automated high-throughput workflow to efficiently functionalize medicinal-chemistry-relevant heteroaryl thioethers with diverse alkyl organozinc reagents in flow. The successful coupling observed with different aryl thioether substrates and organozinc reagents highlights the broad applicability of …

Aminoalkylation of Alkenes Enabled by Triple Radical Sorting

William L. Lyon, Johnny Wang, Jesús Alcázar, David W. C. MacMillan

The direct synthesis of C(sp 3 )-rich architectures is a driving force for innovation in synthetic organic chemistry. Such scaffolds impart beneficial properties onto drug molecules that correlate with greater clinical success. Consequently, there is a strong impetus to develop new methods …

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Primer registro de Eucera (Peponapis) fervens (Smith 1879) abeja de la calabaza y el zapallo en el Perú (Hymenoptera: Apidae)

Verónica Cañedo, Jesús Alcázar, Zelideé Castro, Claus Rasmussen

Se presenta el primer registro de la abeja de la calabaza y el zapallo en el Perú Eucera (Peponapis) fervens (Smith 1879) (Hymenoptera: Apidae), encontrada en los departamentos de Apurímac, Ayacucho, Cusco y Piura polinizando las especies de Cucurbita máxima Duchesne in …

Automated One‐Pot Library Synthesis with Aldehydes as Radical Precursors

Adrián Luguera Ruiz, Brenda Pijper, María Lourdes Linares, Santiago Cañellas et autres

Abstract The increased demand for the synthesis of Csp3 enriched motifs and the urgency of discovering new drugs requires the development of more efficient technologies and synthetic tools to accelerate drug discovery processes. Herein, we report a fully automated strategy for the …

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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome

Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu et autres

The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations …

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