Greenville Children's Hospital

Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants

Matthew Maxwell Laughon, Sonia Thomas, Kristi L. Watterberg, Kathleen A. Kennedy et autres

Importance: The management of patent ductus arteriosus (PDA) in preterm infants is controversial. Objective: To determine whether expectant management compared with active treatment of a protocol-defined PDA in preterm infants decreases the incidence of death or bronchopulmonary dysplasia (BPD). Design, Setting, and …

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Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants

Namasivayam Ambalavanan, Waldemar A. Carlo, Kayla J. Nowak, Laura Elizabeth Wiener et autres

Importance: Extremely preterm infants are at high risk for bronchopulmonary dysplasia (BPD) and death. Multiple small randomized clinical trials showed that a combination of budesonide with surfactant compared with surfactant alone reduced BPD or death. Objective: To determine if early intratracheal administration …

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Influenza-Associated Acute Necrotizing Encephalopathy in US Children

Andrew Silverman, Rachel Walsh, Jonathan Douglas Santoro, Katherine Thomas et autres

Importance: Acute necrotizing encephalopathy (ANE) is a rare, but severe, neurologic condition for which epidemiologic and management data remain limited. During the 2024-2025 US influenza season, clinicians at large pediatric centers anecdotally reported an increased number of children with influenza-associated ANE, prompting …

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Darbepoetin, Red Cell Mass, and Neuroprotection in Preterm Infants

Robin Kjerstin Ohls, Abhik Das, Sylvia Tan, Jean R. Lowe et autres

Importance: Previous studies suggest that administration of erythropoiesis-stimulating agents darbepoetin or erythropoietin to preterm infants results in fewer transfusions, fewer donor exposures, and improved neurodevelopmental outcome. Objective: To determine if, compared with placebo, preterm infants randomized to weekly darbepoetin would have greater …

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Assessment of recurrent fever among children undergoing tonsillectomy

Mana Espahbodi, Kathryn M. Edwards, Steven L. Goudy, Edward B. Penn et autres

BACKGROUND: Recurrent tonsillitis is a common indication for tonsillectomy in children and has phenotypic overlap with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. We sought to characterize symptoms associated with PFAPA among children undergoing tonsillectomy. METHODS: Parents/guardians of children …

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Surgical Risk, Operative Time, and Anesthesia Time Associated With Combining Tracheostomy and Gastrostomy Tube Placement Under a Single Anesthetic

Spencer Cooke, Em Long-Mills, Dmitry Tumin, E Henry et autres

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Implementation of a Multiple Patient Scenario to Enhance Nurse Practitioner Student Role Transition

Theresa Motley, Ann‐Marie Brown

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Pilot and feasibility of the SMART IBD mobile app to improve self‐management in pediatric inflammatory bowel disease

Kevin A. Hommel, Amy E. Noser, Jill M. Plevinsky, Kate Gamwell et autres

OBJECTIVES: Access to evidence-based self-management support in pediatric inflammatory bowel disease (IBD) is a significant challenge. Digital therapeutic solutions can increase access and provide data to patients and providers that would otherwise not be available. We have iteratively developed a mobile application, …

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Spanking or arrest: Caregiver perceptions of the No Hit Zone policy and poster in pediatric clinics

Shaniece Criss, Botamina M Sorial, Len Bowman, Alexandra Pollock et autres

No Hit Zones (NHZs) represent a policy to prevent corporal punishment (CP) and designate specific spaces where hitting is not permitted, including a caregiver spanking a child. For the current study, the aims were to utilize focus groups to 1) understand caregivers’ …

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Delivery of Care for Pediatric Patients Receiving Blinatumomab: A Children’s Oncology Group Study

Janice S. Withycombe, Holly R. Kubaney, Maki Okada, Christine S. Yun et autres

BACKGROUND: Blinatumomab is an immunotherapy agent used in pediatric oncology for the treatment of B-lineage acute lymphoblastic leukemia. Administration of blinatumomab, via continuous 28-day infusion cycles, can present multiple decision points and challenges related to patient care. Nurses are at the forefront …

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Methicillin-Resistant Staphylococcus Aureus (MRSA) Prevalence in Pregnant Women and Transmission Risk to Newborns: Time to Stop Screening

Robin LaCroix

Background: Methicillin-resistant Staphylococcus aureus has become problematic and threatening in an expanded segment of healthy people.Current literature cites an increase in cases of healthy pregnant women and their infants becoming infected or colonized with this organism.Aim: To determine the prevalence of MRSA …

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A Narrative Review of Key Studies in Medical Education in 2021: Applying Current Literature to Educational Practice and Scholarship

Gayatri Boddupalli Madduri, Michael S. Ryan, Jolene E. Collins, Jody N. Huber et autres

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