Janice S. Withycombe

Editorial

Janice S. Withycombe, E Duffy

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Can Steps per Day Reflect Symptoms in Children and Adolescents Undergoing Cancer Treatment?

Molly McFatrich, Sharon M. Castellino, Janice S. Withycombe, Nicole Lucas et autres

BACKGROUND: Multiple symptoms occur in children receiving cancer therapy. Decreased steps per day may be associated with burdensome symptoms. OBJECTIVE: To evaluate associations between self-reported symptoms (pain interference, anxiety, depressive symptoms, psychological stress, and fatigue) and function (physical function-mobility and physical activity) …

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Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review

David R. Freyer, Janice S. Withycombe, Pamela S. Hinds, Molly McFatrich et autres

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Prognostic Impact of KRAS and SMARCA4 Mutations and Co-Mutations on Survival in Non-Small Cell Lung Cancer: Insights from the AACR GENIE BPC Dataset

Peter Manolakos, Yubo Wang, Janice S. Withycombe, Luigi Boccuto et autres

Background/Objectives: KRAS mutations are among the most prevalent oncogenic drivers in non-small cell lung cancer (NSCLC), with their impact on survival influenced by co-mutations. SMARCA4 mutations are increasingly associated with poor prognosis and can be classified as class 1 or class 2 …

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A Rapid Review Exploring Overnight Camps for Children with Chronic or Serious Illness as a Palliative Care Intervention for Caregivers

Tracy Fasolino, Benjamin Parry, Alexandra Skrocki, Janice S. Withycombe et autres

Background: Strong evidence supports the benefits of overnight camp for children with chronic and serious illness, yet little research exists on the role of these camps as a palliative, non-hospice intervention for caregivers. With nearly 25 million children and youth in the …

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Metabolomic Associations With Fatigue and Physical Function in Children With Cancer: A Pilot Study

Janice S. Withycombe, Jinbing Bai, Canhua Xiao, Ronald C. Eldridge

Background: Fatigue is a frequently reported symptom in children undergoing cancer treatment. Prior research shows an inverse relationship between fatigue and physical activity. Less is known about fatigue’s relationship with physical function or the underlying biological mechanisms of fatigue. This study explored …

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Using Wearable Technology to Explore Sleep’s Influence on College Women’s Basketball Performance

Ethan O. Kung, Sarah Stokowski, Janice S. Withycombe, Xinyi Li et autres

Introduction: This study examined the relationship between sleep patterns and athletic performance among NCAA Division I women's basketball players, emphasizing the importance of sleep in recovery and game readiness.Using wearable technology data, this research aimed to identify how sleep metrics influence game …

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Impact of the COVID‐19 Pandemic Onset on the Early Careers of Pediatric Oncology Health Professionals and Researchers: A Report From the Children's Oncology Group Young Investigators Committee, Young SIOP Network, and Young SIOPE

Gemma Bryan, Louise Guolla, Gabriela Villanueva, Sarah Cohen‐Gogo et autres

INTRODUCTION: The COVID-19 pandemic onset had a global debilitating impact on individuals and on burgeoning careers. In 2021, the Children's Oncology Group Young Investigators Committee, Young SIOP (International Society of Paediatric Oncology) Network, and Young SIOPE (European Society for Paediatric Oncology) co-sponsored …

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Sharing Genomic Tumor Sequencing Results With Patients: Experiences of Advanced Practice Oncology Providers

Lisa Stewart, Anne Floyd Koci, Tracy Lowe, Wesley G Patterson et autres

Background: Patients with cancer routinely undergo genomic tumor sequencing, a component of molecular profiling (MP), to better characterize their cancer and identify potential targetable alterations. Targeted treatments potentially confer higher response rates and better efficacy. With increasing complexity, patients may require detailed …

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A Quality Approach to Blinatumomab Delivery in Pediatric Oncology: A Children's Oncology Group Study

Kathleen Montgomery, Sue Zupanec, Christine Yun, Maki Okada et autres

Background: Blinatumomab is a promising immunotherapy agent that has been shown to improve survival outcomes in children diagnosed with relapsed B-lineage acute lymphoblastic leukemia. Expanded use of blinatumomab in the treatment of childhood cancer is expected; however, clinician perspectives regarding administering this …

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Review of the microbiome and metabolic pathways associated with psychoneurological symptoms in children with cancer

Caitlin Webster, Janice S. Withycombe, Jessica Sheth Bhutada, Jinbing Bai

Children with cancer often endure a range of psychoneurological symptoms (PNS), including pain, fatigue, cognitive impairment, anxiety, depressive symptoms, and sleep disturbance. Despite their prevalence, the underlying pathophysiology of PNS remains unclear. Hypotheses suggest an interplay between the gut microbiome and the …

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Delivery of Care for Pediatric Patients Receiving Blinatumomab: A Children’s Oncology Group Study

Janice S. Withycombe, Holly R. Kubaney, Maki Okada, Christine S. Yun et autres

BACKGROUND: Blinatumomab is an immunotherapy agent used in pediatric oncology for the treatment of B-lineage acute lymphoblastic leukemia. Administration of blinatumomab, via continuous 28-day infusion cycles, can present multiple decision points and challenges related to patient care. Nurses are at the forefront …

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