Itaconic acid dissolves TFEB liquid-liquid phase separation to alleviate hyperoxia-induced bronchopulmonary dysplasia
Tengfei Wang, Fengdan Xu, Hui Shi, Rui Long et autres
) and MLE12 cells, we analyzed TFEB LLPS via FRAP, fusion, and in vitro phase separation assays. ITA-TFEB binding was evaluated by surface plasmon resonance (SPR). Autophagic/mitophagic flux and apoptosis were assessed, and the necessity of TFEB was validated using shRNA knockdown …
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Biochemical Pharmacology