Accès ouvert
2026
preprint
OpenAlex
Junrong Xue, Huiqin Xu, Yanfeng Zhang, Xinrong Yu et autres
ABSTRACT Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1), a key regulator of mitophagy, has been linked to the pathogenesis of Parkinson’s disease (PD). PINK1 recruits Parkin, an E3 ubiquitin ligase, triggering mitophagy in response to mitochondrial damage. During mitophagy, the …
cn
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Huiqin Xu, Xinyang Liu, Yating Jiang, Yanfeng Zhang et autres
Abstract Under mitochondrial stress, the mitochondrial kinase PINK1 is activated to phosphorylate ubiquitin, which in turn recruits the E3 ligase Parkin, thereby initiating clearance of damaged mitochondria. Dysregulation of the PINK1–Parkin signaling pathway is associated with early- onset autosomal recessive Parkinson’s disease. …
cn
(code pays fourni par la source)