Extension of Lifespan and Amelioration of Alzheimer’s Disease Phenotypes by Genetic Manipulation of Mitochondrial NAD+/NADH Ratio
Suman Rimal, J. Lee, Yanzi He, Bingwei Lu
Aging remains the most significant risk factor for common neurodegenerative diseases including Alzheimer’s disease (AD). According to the geroscience hypothesis, aging is malleable and that by targeting basic aging physiology, we can alleviate many of the age-related chronic diseases. The common mechanisms …
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Aging and Disease