Suman Rimal

High salt exposure promotes tau hyperphosphorylation and mitochondrial reverse electron transport associated neurodegeneration in Drosophila

J. Kasanin, Benjamin Lu, Xiwei Zheng, Kodi Khau et autres

The pathogenesis of neurodegenerative diseases like Alzheimer’s disease (AD) is complex and involves genetic as well as environmental factors. Previous studies have implicated dietary salt as a risk factor for both AD and cognitive impairment caused by vascular factors. The molecular mechanisms …

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Tau-induced mitochondrial reverse electron transport drives neurodegeneration

Wen Li, Suman Rimal, Sunil Bhurtel, Lucas Yeung et autres

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Dopamine-driven mitochondrial reverse electron transport in immune cells mediates gut–brain ROS signaling during sleep deprivation

Yan Zhang, Jae-Hyuk Lee, Z-F Yu, Yinrui Tao et autres

Sleep deprivation (SD), together with inevitable stress inherent to conventional SD protocols, can induce oxidative stress and inflammation, thereby increasing the risk of premature death. However, the source and signaling pathways underlying reactive oxygen species (ROS) generation remain unclear. Here, we demonstrate …

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Targeting reverse electron transport preserves mitochondrial function and prevents dopaminergic neurodegeneration in Parkinson’s disease

Sunil Bhurtel, Suman Rimal, Wenhua Li, Bingwei Lu

Mitochondrial dysfunction, redox imbalance, and excessive reactive oxygen species (ROS) generation are key pathological hallmarks of Parkinson’s disease (PD). The origin of these defects and their contribution to dopaminergic neurodegeneration remain unclear. Mitochondrial reverse electron transport (RET) reduces NAD + /NADH ratio …

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Tau-induced mitochondrial reverse electron transport drives neurodegeneration

Wen Li, Suman Rimal, Sunil Bhurtel, Lucas Yeung et autres

Abstract Hyperphosphorylation and aggregation of the microtubule-associated protein tau are recognized as pathological hallmarks of tauopathies; however, the biological activity of tau that drives its pathophysiological effects remains poorly understood 1–6 . Mitochondrial dysfunction is a common feature of tauopathies 7,8 . …

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Mitochondrial reverse electron transport regulates glioma stemness through Sirt3-HIF1α-SOX2 signaling

Tejinder Pal Khaket, Suman Rimal, Vishal Chavda, Bingwei Lu

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Extension of Lifespan and Amelioration of Alzheimer’s Disease Phenotypes by Genetic Manipulation of Mitochondrial NAD+/NADH Ratio

Suman Rimal, J. Lee, Yanzi He, Bingwei Lu

Aging remains the most significant risk factor for common neurodegenerative diseases including Alzheimer’s disease (AD). According to the geroscience hypothesis, aging is malleable and that by targeting basic aging physiology, we can alleviate many of the age-related chronic diseases. The common mechanisms …

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Mitochondrial reverse electron transport regulates glioma stemness through Sirt3-HIF1 a-SOX2 signaling

Tejinder Pal, Suman Rimal, Vishal Chavda, Bingwei Lu

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Author response: Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

Jiun Sang, Suman Rimal, Youngseok Lee

Uncovering pharyngeal sour taste receptors in Drosophila melanogaster reveals a novel mechanism for detecting ingested carboxylic acids, expanding understanding of how insects internally sense and respond to appetitive tastants.

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Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

Bhanu Shrestha, Jiun Sang, Suman Rimal, Youngseok Lee

Sour taste, which is elicited by low pH, may serve to help animals distinguish appetitive from potentially harmful food sources. In all species studied to date, the attractiveness of oral acids is contingent on concentration. Many carboxylic acids are attractive at ecologically …

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Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

Jiun Sang, Suman Rimal, Youngseok Lee

Abstract Sour taste, which is elicited by low pH, may serve to help animals distinguish appetitive from potentially harmful food sources. In all species studied to date, the attractiveness of oral acids is contingent on concentration. Many carboxylic acids are attractive at …

kr, us (code pays fourni par la source)

Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

Jiun Sang, Suman Rimal, Youngseok Lee

Sour taste, which is elicited by low pH, may serve to help animals distinguish appetitive from potentially harmful food sources. In all species studied to date, the attractiveness of oral acids is contingent on concentration. Many carboxylic acids are attractive at ecologically …

kr, us (code pays fourni par la source)