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2026
article
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Dan Cheng, Elizabeth McManus, Ryan M. Young, Thomas Oellerich et autres
TAF7, a core subunit of the general transcription factor TFIID, regulates transcription and additionally functions as an RNA chaperone that directs nascent nuclear RNAs to cytoplasmic polysomes, thereby influencing protein synthesis. Here, we identify a set of novel cytoplasmic interactors and a …
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2026
article
OpenAlex
William Gahl, Laura Elnitski, Valer Gotea, David R. Adams et autres
OCA2, a melanosome transmembrane spanning protein, functions to regulate melanosomal pH, optimizing production of melanin pigment. OCA2 is one of eight non-syndromic autosomal recessive oculocutaneous albinism (OCA) loci and is the second most common cause of OCA worldwide. Genome wide association studies …
us
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2012
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OpenAlex
Ian Dunham, Ewan Birney, Javier Herrero, Steven P. Wilder et autres
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and …
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