GPCR crosstalk beyond obligate dimerisation: Effector coincidence detection, compartmentation, and pharmacological implications
Farhad Dehkhoda, Jingjing Xing, Desye Misganaw, Keith Mutunduwe et autres
G protein-coupled receptors (GPCRs) classically signal through cognate heterotrimeric G proteins to regulate second messengers such as cyclic adenosine monophosphate (cAMP) and intracellular Ca 2+ . Yet when two GPCRs are co-expressed, their combined activation can generate emergent outputs, including atypical Ca …
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2 citations
Pharmacology & Therapeutics