William Couet

Prostatic tissue distribution of gepotidacin in patients undergoing prostatectomy: an ex vivo microdialysis and pharmacokinetic modelling study

Valentin al Jalali, Vincent Aranzana-Climent, Anselm Jorda, Felix Bergmann et autres

Objectives The objective of the study was to explore the distribution of gepotidacin into prostate tissue by ex-vivo microdialysis (MD) following a single oral dose of gepotidacin. Methods We developed and validated an ex-vivo MD technique to quantify unbound gepotidacin concentrations in …

at, fr, us, fi, gb (code pays fourni par la source)

Development and validation of a PBPK model of gepotidacin in rats to predict exposure in human prostate

Vincent Aranzana-Climent, Valentin al Jalali, Hwa-Ping Feng, Karen O’Dwyer et autres

International audience

In vitro evaluation of the inoculum effect of various β-lactamase-producing Klebsiella pneumoniae isolates on ceftazidime-avibactam

Alexia Chauzy, William Couet, Isabelle Martin, Hélène Mirfendereski et autres

International audience

PK/PD modelling of the CAMHB nutrients concentrations effect on polymyxin B antimicrobial activity against Acinetobacter baumannii

Mathilde Lacroix, Jérémy Moreau, Claudia Zampaloni, Caterina Bissantz et autres

International audience

In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin

Mathilde Lacroix, Alexia Chauzy, Claudia Zampaloni, Caterina Bissantz et autres

International audience

Comparison between pharmacokinetic-phramcodynamic modeling results of ceftaroline against methicillin-resistant Staphylococcus aureus after Time Kill and Hollow Fiber experiments

Alexia Chauzy, Arthur Fourmy, Hélène Mirfendereski, William Couet et autres

International audience

Use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin

Frédéric Tewes, Chantal Valcourt, William Couet

Colistin is an old polypeptide antibiotic widely used in food-producing animals, particularly in pig production as oral group treatment and metaphylaxis against Enterobacteriaceae digestive infections after weaning. In human, the use of colistin is nowadays recommended as a last resort for the …

Use of PBPK modeling to explore the pharmacokinetics and renal disposition of CMS/Colistin in piglets as a model for the paediatric population

Alexis Viel, Jérôme Henri, William Couet, Michel Laurentie et autres

International audience

Poster Section 10: Antimicrobial Susceptibility Testing

Alexis Viel, Jerome Henri, Agnès Perrin‐Guyomard, Julian Laroche et autres

International audience

The influence of age on colistin methanosulfonate and colistin plasmatic and tissular distribution after intravenous administration of colistin methanosulfonate in pigs background

Alexis Viel, Nicolas Grégoire, Jérôme Henri, Patrice Gobin et autres

International audience