Julian Laroche

PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection.

Frédéric Tewes, Barbara Lamy, Julian Laroche, Isabelle Lamarche et autres

complex-loaded microparticles than that obtained with IV solution.

fr (code pays fourni par la source)

Colistin-loaded aerosolizable particles for the treatment of bacterial respiratory infections

Guillermo Landa, Teresa Alejo, Theo Sauzet, Julian Laroche et autres

es, fr (code pays fourni par la source)

Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate

Romain Carrez, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche et autres

The aim of this study was to investigate the pharmacokinetics of oseltamivir phosphate, a prodrug, and its active moiety in plasma and lung after its nebulization and intravenous administration in rats. Only 2% of prodrug was converted into active moiety presystematically, attesting …

fr (code pays fourni par la source)

Poster Section 10: Antimicrobial Susceptibility Testing

Alexis Viel, Jerome Henri, Agnès Perrin‐Guyomard, Julian Laroche et autres

International audience

A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion

Alexis Viel, Jérôme Henri, Salim Bouchène, Julian Laroche et autres

fr (code pays fourni par la source)

A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion

Alexis Viel, Jérôme Henri, Agnès Perrin‐Guyomard, Julian Laroche et autres

This is a post-peer-review, pre-copyedit version of an article published in 'Pharmaceutical Research'. The final authenticated version is available online at: https://doi.org/10.1007/s11095-018-2379-4. The following terms of use apply: https://www.springer.com/gp/open-access/publication-policies/aam-terms-of-use. Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content …

Lack of experimental evidence to support mcr-1 -positive Escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel, Jérôme Henri, Agnès Perrin‐Guyomard, Julian Laroche et autres

fr (code pays fourni par la source)

The influence of age on colistin methanosulfonate and colistin plasmatic and tissular distribution after intravenous administration of colistin methanosulfonate in pigs background

Alexis Viel, Nicolas Grégoire, Jérôme Henri, Patrice Gobin et autres

International audience

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate

Danilo César Galindo Bedor, Sandrine Marchand, Isabelle Lamarche, Julian Laroche et autres

The aim of this study was to determine the biopharmaceutical characteristics of oseltamivir carboxylate (OC) after pulmonary delivery. After OC bolus and intratracheal nebulization (NEB) in rats, blood was collected and bronchoalveolar lavages (BALs) were performed. Epithelial lining fluid (ELF) concentrations were …

fr, br (code pays fourni par la source)

Lack of a pharmacokinetic interaction between oral famciclovir and allopurinol in healthy volunteers

Susan E. Fowles, Sue Pratt, Julian Laroche, William Prince

us, gb (code pays fourni par la source)

Linear pharmacokinetics of penciclovir following administration of single oral doses of famciclovir 125, 250, 500 and 750 mg to healthy volunteers

M. A. Pue, Sue Pratt, Amanda J. Fairless, Susan E. Fowles et autres

Twenty healthy male volunteers received single oral doses of famciclovir (125-750 mg), in a randomized, single-blind, crossover study. Plasma and urine concentrations of penciclovir and its 6-deoxy precursor, BRL 42359, were determined and penciclovir plasma concentration-time data submitted to model-independent pharmacokinetic analysis. …

us, gb (code pays fourni par la source)

Pharmacokinetics of pantoprazole following single intravenous and oral administration to healthy male subjects

M. A. Pue, Julian Laroche, Ingolf Meineke, Christian de Mey

us, gb (code pays fourni par la source)