Simultaneous single-base resolution profiling of 5mC and 5hmC using BRIGHT-seq
Xiaochen Xue, Ziang Lu, Wei Yang, Shaoqing Han et autres
Cytosine modifications in DNA, particularly 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), are key epigenetic marks involved in gene regulation and chromatin organization. Simultaneous and base-resolution detection of 5mC and 5hmC is essential for understanding their interplay in gene regulation. However, existing methods often …
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National Science Review