Haofeng Lin

The use of antibiotic, probiotic, and fecal microbiota transplantation in modulating immunotherapy efficacy and survival: a systematic review and meta-analysis of clinical outcomes

Zijun Zhai, Shuling Ma, Shijie Shang, Xinyi Liang et autres

BACKGROUND: Immune checkpoint inhibitors (ICIs) have been one of the important therapeutic approaches for patients with advanced malignancies; nevertheless, their clinical efficacy remains limited in many patients. Recently, the contribution of intestinal microbiota to improved antitumor immune responses has gradually been recognized. …

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Copper overload drives hepatic stellate cell activation via cuproptosis to exacerbate acute liver injury in murine malaria

Xiumei Mo, Qian Chen, Rui Zhong, Yannan Lin et autres

Abstract Background Acute liver injury, a critical complication of severe malaria, was characterized by hepatocyte death and hepatic stellate cell (HSC) activation. While HSC activation was a well-established driver of chronic liver fibrosis, its specific role and the triggers initiating it during …

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Additional file 1 of Copper overload drives hepatic stellate cell activation via cuproptosis to exacerbate acute liver injury in murine malaria

Xiumei Mo, Qian Chen, Rui Zhong, Yannan Lin et autres

Supplementary material 1. Table 1. Primer sequences used in the qPCR analysis of target cytokines. All forward (F) and reverse (R) primers for qPCR analysis were designed and synthesized by Sangon Biotech (Shanghai, China).

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Additional file 1 of Copper overload drives hepatic stellate cell activation via cuproptosis to exacerbate acute liver injury in murine malaria

Xiumei Mo, Qian Chen, Rui Zhong, Yannan Lin et autres

Supplementary material 1. Table 1. Primer sequences used in the qPCR analysis of target cytokines. All forward (F) and reverse (R) primers for qPCR analysis were designed and synthesized by Sangon Biotech (Shanghai, China).

cn, ca (code pays fourni par la source)

IDDF2026-ABS-0145 Antibiotics and probiotics differentially shape immunotherapy outcomes in non-small cell lung cancer

Shuling Ma, Zijun Zhai, Shijie Shang, Xinyi Liang et autres

Background Gut microbiota may influence the efficacy of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC), but the clinical impact of microbiota-modulating interventions remains unclear. We conducted a meta-analysis to assess the associations of antibiotics and probiotics with immunotherapy outcomes …

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IDDF2026-ABS-0120 The use of antibiotic, probiotic, and FMT in modulating immunotherapy efficacy and survival

Zijun Zhai, Shuling Ma, Shijie Shang, Xinyi Liang et autres

Background Immune checkpoint inhibitors (ICIs) have been one of the important therapeutic approaches for advanced malignancies; nevertheless, suboptimal treatment efficacy remains a challenge in a proportion of patients. Recently, the contribution of intestinal microbiota to improved antitumor immune responses has gradually been …

cn, hk (code pays fourni par la source)

Antibiotics and probiotics differentially shape immunotherapy outcomes in non-small cell lung cancer

Shuling Ma, Zijun Zhai, Rui Ding, Shijie Shang et autres

cn, hk (code pays fourni par la source)