Xiumei Mo

Mechanism of Gu‐Ben‐Hua‐Shi ( AESS ) Formula Regulating Autophagy Through Hippo‐ YAP Pathway in Restoring the Skin Barrier in Atopic Dermatitis

Xin Ma, Yiting Huang, Xiao Lv, Xiumei Mo et autres

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and immune balance disorders. Currently, drugs for repairing the skin barrier in AD are limited. The gu-ben-hua-shi formula (AESS) has been shown to regulate Th1/Th2/Th17/Treg imbalance with good …

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Copper overload drives hepatic stellate cell activation via cuproptosis to exacerbate acute liver injury in murine malaria

Xiumei Mo, Qian Chen, Rui Zhong, Yannan Lin et autres

Abstract Background Acute liver injury, a critical complication of severe malaria, was characterized by hepatocyte death and hepatic stellate cell (HSC) activation. While HSC activation was a well-established driver of chronic liver fibrosis, its specific role and the triggers initiating it during …

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Additional file 1 of Copper overload drives hepatic stellate cell activation via cuproptosis to exacerbate acute liver injury in murine malaria

Xiumei Mo, Qian Chen, Rui Zhong, Yannan Lin et autres

Supplementary material 1. Table 1. Primer sequences used in the qPCR analysis of target cytokines. All forward (F) and reverse (R) primers for qPCR analysis were designed and synthesized by Sangon Biotech (Shanghai, China).

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Additional file 1 of Copper overload drives hepatic stellate cell activation via cuproptosis to exacerbate acute liver injury in murine malaria

Xiumei Mo, Qian Chen, Rui Zhong, Yannan Lin et autres

Supplementary material 1. Table 1. Primer sequences used in the qPCR analysis of target cytokines. All forward (F) and reverse (R) primers for qPCR analysis were designed and synthesized by Sangon Biotech (Shanghai, China).

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Synergistic Effect of Topographical Cue and Local Drug Delivery: An Axially-Aligned AM80-Loaded Graft for Preventing Intimal Hyperplasia in Small-Diameter Vascular Grafts

Fubang Liang, Xinyi Li, Fengqing Yin, Dawei Jin et autres

Small-diameter vascular grafts (SDVGs) continue to present significant clinical challenges due to their poor long-term patency, which primarily results from incomplete endothelialization and intimal hyperplasia (IH). Inspired by the structure of natural blood vessels, this study developed a bilayered electrospun vascular graft. …

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Hierarchically structured fiber scaffold incorporating functionalized microspheres for sustained drug release and treatment of infected wounds

Gonghao Zhang, Sidong Zhang, Lu Han, Zhengchao Yuan et autres

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A 3D-printed composite scaffold with sequential release of graphene oxide/hydroxyapatite synergistically enhances angiogenesis-osteogenesis for bone defect repair

Chunchun Li, C. Lyu, Yangfan Ding, Ziying Feng et autres

Angiogenic and osteogenic factors coordinate bone repair through time-dependent regulation of cellular responses, ensuring synchronized neovascularization and osteogenesis. Therefore, we designed a framework using polycaprolactone (PCL) and hydroxyapatite (HAp), which was then filled with a gelatin (GEL) matrix containing graphene oxide (GO) …

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Yes-associated protein regulates autophagy to restore skin barrier function in atopic dermatitis

Jinjing Jia, Xin Ma, Tongfei Wang, Siqi Ye et autres

Introduction Atopic dermatitis (AD) is characterized by skin barrier dysfunction and inflammation.This study explored the relationship between Yes-associated protein (YAP) expression, autophagy, and skin barrier dysfunction in AD. Methods Skin samples from AD patients and healthy controls were analyzed using mRNA-seq. Differential …

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Cuproptosis-driven astrocyte reactivity exacerbates experimental cerebral malaria pathogenesis

Xinpeng Hou, Xiumei Mo, Xiaoran Zhang, Qi Wang et autres

Abstract Background Cerebral malaria (CM), a lethal neurological complication of Plasmodium falciparum , is characterized by blood–brain barrier (BBB) disruption. Although astrocytes constitute essential components of the BBB neurovascular unit, their immunoregulatory functions during CM pathogenesis remain elusive. Clinical evidence of altered …

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When to Reason: Semantic Router for vLLM

Chen Wang, Xunzhuo Liu, Yuhan Liu, Yue Zhu et autres

Large Language Models (LLMs) demonstrate substantial accuracy gains when augmented with reasoning modes such as chain-of-thought and inference-time scaling. However, reasoning also incurs significant costs in inference latency and token usage, with environmental and financial impacts, which are unnecessary for many simple …

Hyaluronic acid–hydroxyapatite composite hydrogels for tissue filling and soft tissue regeneration

Zhengchao Yuan, Lei Zheng, Jianmei Huang, Chao Huang et autres

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Biomimetic Multilayered Gas‐Foaming Scaffold with Sustained bFGF Delivery for Annulus Fibrosus Regeneration

Yujie Chen, Yucai Li, Zhenyuan Wei, Lin Du et autres

Current clinical treatments for intervertebral disc (IVD) herniation (e.g., discectomy) often lead to re-herniation, and tissue engineering scaffolds for annulus fibrosus (AF) regeneration remain scarce, particularly those capable of mimicking the multilayered structure of native AF. This study combines electrospinning with gas-foaming …

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