Melissa Lamar

Associations of polygenic scores for sleep traits with cognitive function

Xinye Qiu, Annah Wyss, Yu Zhang, Brian Spitzer et autres

Abstract INTRODUCTION Polygenic scores (PGSs) for sleep traits are potentially more stable, and less subject to confounding than measured sleep traits. Leveraging data from five observational cohorts, we aim to assess the associations between PGS for six common sleep traits, and global …

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Lasting effects of redlining: The association of historical redlining and cognitive function in older Black adults

Brittney S. Lange‐Maia, Melissa Lamar, Jason LaBrosse, Ana W. Capuano et autres

BACKGROUND: Residing in a formerly redlined community is often associated with worse health. Few studies have studied redlining and late-life cognition; none have examined multiple cognitive domains. METHODS: Black older adults (N = 676, mean baseline age 74.1 [SD: 6.5] years, 78.2% …

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Multimodal Associations of Modifiable Risk Factors on White Matter Injury: The SOL-INCA-MRI Study (HCHS/SOL).

Richard B Lipton, Christian Agudelo, Kevin A Gonzalez, Martha Daviglus et autres

BACKGROUND: Modifiable risk factors play a central role in the development and course of neurodegenerative disorders of later life, including dementias. Although past research has focused on independent associations of modifiable risk factors, including cardiovascular disease risk factors using Framingham cardiovascular risk …

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Regional juxtacortical microstructural changes and gene expression provide insights into neurodegeneration in Alzheimer’s disease

Junfang Zhang, Lipeng Sun, Xinyuan Yang, Lin Kang et autres

White matter microstructural changes play a crucial role in cognitive decline in aging and neurodegenerative disorders including Alzheimer's disease (AD). However, the processes underlying white matter microstructural changes and the molecular pathways leading to these changes in AD remain largely unknown. AD …

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Social vulnerability index and inflammation: a proteomic analysis linking social context to biological risk in older black adults

Anat Yaskolka Meir, Henry A. Adeola, Shinya Tasaki, Liming Liang et autres

Inflammation is a key driver of age-related disease and has been associated with social conditions. We examined how cumulative community-level social and structural disadvantage is associated with inflammatory proteomic profiles in older Black adults. We employed data from the Minority Aging Research …

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Mexican Teachers’ Cohort Cognitive Study: A pilot of home‐based assessments

Jocelyn Jaen, Adrián Cortés-Valencia, Aarón Salinas Rodríguez, Betty Manrique-Espinoza et autres

INTRODUCTION: Expanding research on aging and cognition in low- and middle-income countries is critical, yet logistically complex. Large, established cohorts, such as the Mexican Teachers' Cohort (MTC; >100,000 women), pose unique opportunities for neurocognitive research in Latin America. METHODS: We evaluated the …

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The Modifying Effect of Individual-Level Neighborhood Perceptions on the Relationship Between Census-Level Neighborhood Social Vulnerability and Cognition in Older Latinos

Melissa Lamar, Cheyenne V. Parson, Crystal M. Glover, Ana W. Capuano et autres

Residents of vulnerable neighborhoods show lower levels of, and faster longitudinal declines in cognition across most, but not all studies. Mixed results may exist, in part, because residents’ self-reported (individual-level) perceptions of their neighborhood do not always reflect Census-level measurements. We investigated …

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The role of life‐course socioeconomic position in cognitive change and mild cognitive impairment among middle‐aged and older US Hispanic/Latinos

Melissa Lamar, Linda C. Gallo, Ariana M. Stickel, Hector M Gonzalez et autres

INTRODUCTION: The role of life-course socioeconomic position (SEP) in cognitive aging remains unclear. We assessed the association between life-course SEP with cognitive change and prevalent mild cognitive impairment (MCI). METHODS: We used data from the Hispanic Community Health Study/Study of Latinos (2008 …

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Associations of cognitive activity and access to resources with cognitive decline in a broad representation of older adults

Mayra L. Estrella, Maude Wagner, Robert S. Wilson, Lisa L. Barnes et autres

INTRODUCTION: Little is known about whether the cognitive benefits of cognitive activities and resources differ across ethno-racial groups in late-life. METHODS: Participants were 1702 non-Latino White, 766 non-Latino Black, and 324 Latino adults (≈ 76 years; N = 2792). Linear mixed-effects models …

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Helping the Helper: LLM-Assisted Problem Articulation for Older Adults Seeking Technology Support

Hasti Sharifi, Homaira Huda Shomee, Melissa Lamar, Sourav Medya et autres

Older adults often struggle to articulate technology support needs due to unfamiliar technical terminology and age-related cognitive changes. We explore how large language models (LLMs) can facilitate this problem articulation process. Through a diary study (n = 27), we identified four communication …

Helping the Helper: LLM-Assisted Problem Articulation for Older Adults Seeking Technology Support

Hasti Sharifi, Homaira Huda Shomee, Melissa Lamar, Sourav Medya et autres

Older adults often struggle to articulate technology support needs due to unfamiliar technical terminology and age-related cognitive changes. We explore how large language models (LLMs) can facilitate this problem articulation process. Through a diary study (n = 27), we identified four communication …

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