One PPI may not fit all—prevalence of CYP2C19 phenotypes in patients with Barrett’s esophagus
Keouna Pather, Abdel-Rahman Naser, Erin M. Mobley, Estefania Garcia et autres
us (code pays fourni par la source)
0 citations
Surgical Endoscopy
Emily J. Cicali
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8Publications signalées
4Citations signalées
5Affiliations récentes
Les institutions déclarées
Les domaines associés
Pharmacogenetics and Drug MetabolismGastroesophageal reflux and treatmentsColorectal Cancer Treatments and StudiesCancer therapeutics and mechanismsLung Cancer Research Studies
Les publications récentes
Considerations for the clinical implementation of DPYD and UGT1A1-guided chemotherapy
Mary-Pearl Ojukwu, Carlos Vegas, Emily J. Cicali, David L. DeRemer et autres
Existing literature demonstrates the benefits of DPYD and UGT1A1 pharmacogenetic (PGx) testing to reduce toxicity from fluoropyrimidines and irinotecan, respectively. The Food and Drug Administration (FDA) has provided UGT1A1-guided irinotecan dosing for 20 years, and in 2025, the FDA and National Comprehensive …
0 citations
Figshare
Considerations for the clinical implementation of DPYD and UGT1A1-guided chemotherapy
Mary-Pearl Ojukwu, Carlos Vegas, Emily J. Cicali, David L. DeRemer et autres
Existing literature demonstrates the benefits of DPYD and UGT1A1 pharmacogenetic (PGx) testing to reduce toxicity from fluoropyrimidines and irinotecan, respectively. The Food and Drug Administration (FDA) has provided UGT1A1-guided irinotecan dosing for 20 years, and in 2025, the FDA and National Comprehensive …
0 citations
Figshare
Genetic variations in medical versus surgical patients with GERD: beyond PPIs and fundoplications
Abdel-Rahman Naser, Keouna Pather, Erin M. Mobley, Masoud Rouhizadeh et autres
us, cn (code pays fourni par la source)
0 citations
Surgical Endoscopy
Considerations for the clinical implementation of DPYD and UGT1A1-guided chemotherapy
Mary-Pearl Ojukwu, Carlos Vegas, Emily J. Cicali, David L. DeRemer et autres
Existing literature demonstrates the benefits of DPYD and UGT1A1 pharmacogenetic (PGx) testing to reduce toxicity from fluoropyrimidines and irinotecan, respectively. The Food and Drug Administration (FDA) has provided UGT1A1-guided irinotecan dosing for 20 years, and in 2025, the FDA and National Comprehensive …
us (code pays fourni par la source)
0 citations
Pharmacogenomics
Prevalence of CYP2C19 phenotypes in patients undergoing a hiatal hernia repair
Abdel-Rahman Naser, Keouna Pather, Erin M. Mobley, Brandon Climenhage et autres
OBJECTIVES: Gastroesophageal reflux disease is primarily treated with proton pump inhibitors (PPIs), which are metabolized by cytochrome P450 2C19 ( CYP2C19 ) in the liver. CYP2C19 polymorphisms affect PPI plasma levels, with rapid (2-27%) and ultra-rapid (<1-5%) metabolizers needing higher doses, while …
us (code pays fourni par la source)
0 citations
Pharmacogenetics and Genomics
Genotype-Guided Antidepressant Prescribing for Patients With Depression
Kathryn Blake, Lindsay J. Hines, Michelle Liu, Rachel A. Myers et autres
Importance: The effectiveness of pharmacogenetics to guide prescribing of selective serotonin reuptake inhibitors (SSRIs) for depression remains unclear, despite the well-established association between SSRI pharmacokinetics and genetic variation. Objective: To determine whether pharmacogenetic-guided prescribing of SSRIs improves treatment response in patients with …
us, gb (code pays fourni par la source)
4 citations
JAMA Network Open
Prevalence of CYP2C19 polymorphisms in medically and surgically managed patients with GERD
Abdel-Rahman Naser, Keouna Pather, Erin M. Mobley, Amy Crisp et autres
us (code pays fourni par la source)
0 citations
Surgery
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