Accès ouvert
2026
article
OpenAlex
Hojun Jung, Bada Jeong, Yong-Woo Kim, Chanju Jung et autres
Replacing large-scale fragments in human cells remains a substantial challenge. Here, we present a programmable gene replacement tool, named prime assembly (PA), which adapts prime editors to produce one or two pairs of 3'-flaps on both the genome and donor DNA. These …
kr, us, pr, am
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Hyeon Woo Im, Bada Jeong, Yeji Lee, Ye Eun Oh et autres
Adenine base editors (ABEs), which enable A•T-to-G•C base editing, have emerged as a powerful tool with potential therapeutic applications. However, conventional ABEs suffer from bystander nucleotide conversions, limiting their utility for precise editing. Here we present a single-nucleotide resolution ABE (snuABE) created …
kr, us, pr, am
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Yeji Lee, Hyeonguk Baek, Jihwan Lee, Dajeong Lim et autres
Practical, rapid, and cost-efficient screening tools are needed to verify A2 milk purity and support selective breeding programs. Although several genotyping methods are available, their routine implementation is often limited by equipment costs and labor-intensive post-PCR processing. We hypothesized that combining allele-specific …
kr
(code pays fourni par la source)