SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang et autres
ABSTRACT Liver transplantation (LT) grafts exhibit selective pericentral hepatic ischemia‐reperfusion injury (HIRI), but the zonal mechanism is unclear. To address this, we integrated single‐cell and spatial transcriptomics with chromatin accessibility profiling, proteomics, and bulk RNA‐seq, then validated key findings in clinical LT …
cn (code pays fourni par la source)
2 citations
Advanced Science