Megan Grove

Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants

Sharon L. R. Kardia, Charles Kooperberg, Yesha M. Patel, Huichun Xu et autres

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Cross-population metabolome-wide Mendelian randomization study of prostate cancer risk

Harriett Fuller, Rebecca Rohde, Heather M. Highland, Jeffrey Haessler et autres

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Abstract 68: Metabolomic Profiles of Cardiac Structure and Function and Their Associations with Incident Heart Failure in Multi-Ethnic Populations

Eun Hye Moon, Taryn Alkis, Kai Luo, Shinhye Chung et autres

Introduction: Metabolic dysregulation is associated with heart failure (HF). However, comprehensive evaluation of the effect of circulating metabolites on cardiac function, a critical measure for predicting HF risk and prognosis, in multi-ethnic populations remains limited. Objectives: We aim to identify circulating metabolites …

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Abstract 01: An Atlas of Circulating Metabolites Associated with Incident Coronary Heart Disease in ~23,000 Racially and Ethnically Diverse Adults

Kai Luo, Taryn Alkis, Eun Hye Moon, Huan Yun et autres

Background: A comprehensive, replicated atlas of circulating metabolites for incident coronary heart disease (CHD) across race diverse populations is lacking and metabolite signatures of early-onset CHD remain largely unidentified. Methods: We conducted a two-stage metabolome wide-association analysis using Cox regression model for …

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Abstract TH957: Performance of Cardiometabolic Polygenic Scores in a high-altitude Peruvian Population

Andy Castaneda, Natalie R. Hasbani, Adam S. Heath, Osvaldo Alquicira et autres

Background: Polygenic scores (PGS) aggregate the effects of multiple genetic variants to estimate disease risk. Limited ancestral diversity in discovery and validation datasets may reduce performance in underrepresented populations. We evaluated the transferability of associations for existing PGS for cardiometabolic phenotypes in …

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Abstract 18: Association of Serum Metabolic Profiles with Mortality and Longevity: The Trans-Omics for Precision Medicine (TOPMed) Study

Peidi Zhou, Taryn Alkis, Shinhye Chung, Eun Hye Moon et autres

Introduction: All-cause and cause-specific mortality remain major measures of public health burden, despite the rising number of individuals achieving longevity (≥85 years). Although many mortality-related metabolites have been identified, metabolite predictors of long-term mortality and longevity across diverse populations remain understudied. We …

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Abstract MPWE44: A multi-ancestry blood metabolites atlas of incident stroke in ~39,000 adults

Kai Luo, Taryn Alkis, Eun Hye Moon, Christie Mitchell Ballantyne et autres

Background: A comprehensive blood metabolome fingerprint of incident stroke and the temporal variation of metabolite levels across pre-diagnostic trajectories remain poorly defined. Methods: We included 38,594 stroke-free adults from seven multi-ethnic TOPMed cohorts with 1,245 named circulating metabolites ( Fig1.a ). Incident …

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Additional file 1: of Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

Abhay Raina, Xiaoping Zhao, Megan Grove, Jan Bressler et autres

Top 100 CpGs from the epigenome-wide association study (EWAS) of WMH burden in ARIC African-Americans. Association P-value, effect size, and standard error for each probe are shown as well as location(chromosome, position) and probe type. (PDF 195 kb)

Additional file 1: of Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

Abhay Raina, Xiaoping Zhao, Megan Grove, Jan Bressler et autres

Top 100 CpGs from the epigenome-wide association study (EWAS) of WMH burden in ARIC African-Americans. Association P-value, effect size, and standard error for each probe are shown as well as location(chromosome, position) and probe type. (PDF 195 kb)