Abstract 68: Metabolomic Profiles of Cardiac Structure and Function and Their Associations with Incident Heart Failure in Multi-Ethnic Populations
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Le résumé fourni par la source
Introduction: Metabolic dysregulation is associated with heart failure (HF). However, comprehensive evaluation of the effect of circulating metabolites on cardiac function, a critical measure for predicting HF risk and prognosis, in multi-ethnic populations remains limited. Objectives: We aim to identify circulating metabolites associated with cardiac function and HF risk in multi-ethnic populations. Methods: We evaluated 21,638 HF-free participants (57% non-White, 57% women) from seven studies, who had contemporaneous circulating metabolite and echocardiography (echo) measures. We used linear regressions (within study) to evaluate the cross-sectional associations between metabolites and cardiac structure/function traits, adjusting for clinical risk factors. Random-effect meta-analyses were performed to produce overall estimates. Cox proportional hazard regression was used to examine the association of echo-related metabolites with incident HF, and its subsets, HF with reduced and preserved ejection fraction (HFrEF, HFpEF). Results: Of 1,027 analyzed metabolites in relation to 42 echo measures, 604 were significantly associated with 28 echo measures (FDR <0.05), including cardiac structure and left and right ventricular function traits. In the prospective analyses, 156, 59, and 73 metabolites showed a significant association with incident HF, HFrEF, and HFpEF, with an average hazard change of 21%, 13%, and 32% per SD difference in metabolite level. Many identified metabolites showed consistent effects across echo measures and HF risk (Figure). High levels of acisoga, an end-product of polyamine metabolism and a potential biomarker for HF, were associated with greater left atrial size and HFpEF risk; high levels of homoarginine, an amino acid with anti-inflammatory properties, were associated with low left ventricular mass and a lower risk for HFrEF and HFpEF. Some metabolites demonstrated divergent effects-high levels of glycerol, a precursor for the synthesis of triacylglycerols and phospholipids, were associated with low left ventricular mass yet a high risk of HFrEF. Conclusions: Metabolomic profiling revealed distinct and mostly consistent associations between circulating metabolites, cardiac structure/function, and incident HF in multi-ethnic populations. Our findings provide insights into the metabolic pathways underlying cardiac remodeling and HF pathogenesis, and raise the possibility that novel metabolites may inform HF risk stratification.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstract 68: Metabolomic Profiles of Cardiac Structure and Function and Their Associations with Incident Heart Failure in Multi-Ethnic Populations
- Date Crossref
- 24/03/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Texas Health Science Center at Houston pays non établi dans la noticeUniversité ou école supérieure
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Albert Einstein College of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Cedars-Sinai Medical Center pays non établi dans la noticeÉtablissement de santé
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Broad Institute pays non établi dans la noticeOrganisation à but non lucratif
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Beth Israel Deaconess Medical Center pays non établi dans la noticeÉtablissement de santé
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The University of Texas Health Science Center at Houston, Albert Einstein College of Medicine et Cedars-Sinai Medical Center, avec 9 autres affiliations.
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