Accès ouvert
2026
preprint
OpenAlex
Marvin Thielert, Enes Ugur, Maximilian Zwiebel, Marc Oeller et autres
Summary Bulk transcriptome and proteome correlate only modestly, but this has not been investigated in the same cell or across cell-state changes. Here we introduce a scalable technology that quantifies thousands of proteins and transcripts in the same cell, separating RNA from …
de, ch, se
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Veijo T. Salo, Yoel A. Klug, Jennifer Sapia, Justin C. Deme et autres
Lipid droplets (LDs) are key organelles in cellular lipid homeostasis that form at the endoplasmic reticulum (ER) through a sequence of membrane rearrangements. While seipin emerged as an essential protein complex for LD biogenesis, how seipin-mediated LD formation proceeds beyond the initial …
de, gb, ch, us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Kathrin Korff, Lukas T. Henneberg, Denys Oliinyk, Nils Eikmeier et autres
Abstract Sample preparation increasingly sets the throughput and reproducibility of mass spectrometry (MS)-based proteomics. StageTips (stop-and-go extraction tips) and variants thereof have long been common implements to purify samples, and we recently extended the concept to solid-phase extraction capture (SPEC) tips, in …
de
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Kai Fenzl, Linda Helena Müller, Julia Kornienko, Maria Majchrowska et autres
Abstract Multiplex assays of variant effects have linked thousands of genotypes to fitness effects, yet we lack profound understanding of how variants impact molecular phenotypes. Here, we introduce a deep mutational scanning framework that quantifies disease-determining molecular phenotypes in human cells, allowing …
de, us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Tim Heymann, Denys Oliinyk, Lukas T. Henneberg, Michal Lorenz et autres
Abstract Mass spectrometry-based proteomics increasingly demands platforms that combine quantitative rigor with the discovery capabilities of accurate mass systems. Here we present the ZenoTOF 8600 system, a compact mass spectrometry system that integrates enhanced ion capture and transmission optics with an optical …
de
(code pays fourni par la source)