Poolakkad S. Satheeshkumar

Complement Factor H Regulates a Complement-Extracellular Vesicle-Macrophage Axis in Immune Mediated Kidney Injury

Aum Campanieri, Shane Fraher, Poolakkad S. Satheeshkumar, Jessica Reynolds et autres

Introduction: Complement Factor H (FH) regulates the alternative complement pathway, and FH deficiency promotes complement activation, macrophage recruitment, and renal injury. Extracellular vesicles (EVs) mediate intercellular communication and may provide molecular signatures of tissue inflammation.Methods: We examined complement- and macrophage-associated transcriptional signatures …

Complement Factor H Regulates a Complement-Extracellular Vesicle-Macrophage Axis in Immune Mediated Kidney Injury

Aum Campanieri, Shane Fraher, Poolakkad S. Satheeshkumar, Jessica Reynolds et autres

Introduction: Complement Factor H (FH) regulates the alternative complement pathway, and FH deficiency promotes complement activation, macrophage recruitment, and renal injury. Extracellular vesicles (EVs) mediate intercellular communication and may provide molecular signatures of tissue inflammation.Methods: We examined complement- and macrophage-associated transcriptional signatures …

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Complement Factor H Regulates a Complement-Extracellular Vesicle-Macrophage Axis in Immune Mediated Kidney Injury

Aum Campanieri, Shane Fraher, Poolakkad S. Satheeshkumar, Jessica Reynolds et autres

Introduction: Complement Factor H (FH) regulates the alternative complement pathway, and FH deficiency promotes complement activation, macrophage recruitment, and renal injury. Extracellular vesicles (EVs) mediate intercellular communication and may provide molecular signatures of tissue inflammation.Methods: We examined complement- and macrophage-associated transcriptional signatures …

Long-Term Clinical Consequences of Severe Oral Mucositis in Survivors of Lip, Oral Cavity and Pharynx Cancer Versus Leukemia: A Propensity-Score-Matched Comparative Cohort Study Using Real-World Data

Poolakkad S. Satheeshkumar, Venu Pararath Gopalakrishnan, Joel B. Epstein, Roberto Pili

Background/Objectives Severe oral mucositis is widely viewed as a transient toxicity of antineoplastic therapy. Whether its long-term consequences differ between cancers that directly damage the upper aerodigestive tract (lip, oral cavity, pharynx [CLOP]) and systemic hematologic malignancies is unknown. To compare lifetime …

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Prolonged Hospital Discharge Timing and Oral-Systemic Complications in Hematopoietic Stem Cell Transplant Recipients with Ulcerative Mucositis

Sana Raheem, Kapil Sankar Meleveedu, Stephanie J. M. van Leeuwen, Lucky L. A. van Gennip et autres

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Complement at the Nano–Neuroimmune Interface: A Hypothesis-Driven Perspective on Opioid Use Disorder

Alexander Jacob, Harbir Singh, Poolakkad S. Satheeshkumar, Aum Champaneri et autres

The complement system is a central component of innate immunity with established roles in host defense and emerging functions in neurodevelopment, synaptic remodeling, and neuroimmune communication within the central nervous system (CNS). In parallel, advances in nanotechnology have not only enabled targeted …

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