John Clarke

Cover Image

Chris Varghese, Nicky Dachs, Gabriel Schamberg, Thomas Abell et autres

The cover image is based on the article Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: ‘Auckland Classification’ v1.0 by Chris Varghese et al., https://doi.org/10.1111/nmo.70377.

Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: ‘Auckland Classification’ v1.0

Chris Varghese, Nicky Dachs, Gabriel Schamberg, Thomas Abell et autres

INTRODUCTION: Chronic gastroduodenal disorders remain challenging to manage, and new diagnostic approaches are needed to better delineate underlying causes and guide therapeutic decisions. Body Surface Gastric Mapping (BSGM) technologies combine high-resolution gastric myoelectrical activity measurements with symptom and psychological profiling to provide …

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Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke et autres

OBJECTIVE: The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification. METHODS: This …

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Artificial Intelligence Chatbots for Dysphagia Patient Education: A Multi‐Center International Expert Evaluation

Luisa Bertin, Afrin K. Rahman, John Clarke, Amir Mari et autres

BACKGROUND: Patients increasingly consult artificial intelligence (AI) chatbots for health information, yet the reliability and accessibility of AI-generated content for complex conditions like dysphagia remain unvalidated. We conducted the first head-to-head comparison of leading large language models for dysphagia patient education, evaluated …

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Autonomic Dysfunction in Gastroduodenal Disorders Evaluated Through Multimodal Non-Invasive Physiological Testing

Chris Varghese, Wendy Zhou, Armen A. Gharibans, Gabriel Schamberg et autres

INTRODUCTION: Chronic gastroduodenal disorders are highly prevalent and encompass heterogeneous pathophysiology. Autonomic dysfunction may contribute, but its relative contribution to disease pathophysiology and symptoms is unclear. This study aimed to clarify the contributions of autonomic dysfunction in gastroduodenal disorders and symptom associations …

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Expert recommendations for the management of refractory gastro-oesophageal reflux disease in systemic sclerosis: a report from the World Scleroderma Foundation (WSF) Gastrointestinal ‘Ad hoc committee’

Michael Hughes, Anna Lo Cricchio, Maria Cristina De Santis, Luis G Alcala-Gonzalez et autres

Background: Gastro-esophageal reflux disease (GERD) occurs in most (~75%) patients with systemic sclerosis (SSc) and significantly impacts quality of life. Current recommendations lack depth and therefore, our aim was to produce practical, consensus-based recommendations for refractory SSc-related GERD. Methods: An international, multidisciplinary …

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Expert recommendations for the management of faecal incontinence in systemic sclerosis: a report from the World Scleroderma Foundation gastrointestinal ‘ad hoc committee’

Zsuzsanna H McMahan, Maria Cristina De Santis, Anna Lo Cricchio, Luis G Alcala-Gonzalez et autres

Background: Fecal incontinence (FI) affects up to 50% of patients with systemic sclerosis (SSc), significantly impairing quality of life and daily functioning. Despite its prevalence, patients may not disclose their symptoms and there is limited guidance on evaluation and management. Given the …

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