Expert recommendations for the management of refractory gastro-oesophageal reflux disease in systemic sclerosis: a report from the World Scleroderma Foundation (WSF) Gastrointestinal ‘Ad hoc committee’
Rattachement africain : gb, it, ps, es, us, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Gastro-esophageal reflux disease (GERD) occurs in most (~75%) patients with systemic sclerosis (SSc) and significantly impacts quality of life. Current recommendations lack depth and therefore, our aim was to produce practical, consensus-based recommendations for refractory SSc-related GERD. Methods: An international, multidisciplinary Steering Board (SB) was assembled (n=19) consisting of clinicians (rheumatologists, gastroenterologists, GI surgeons), an expert methodologist, and patient representation. After reviewing the latest definitions of GERD and refractory GERD in the published literature, the SB collectively devised a practical definition of SSc refractory-GERD. Initial recommendations were drafted/agreed upon by the SB based on review of the existing guidelines, published literature, and expert opinion. Two online voting rounds were conducted to determine whether items should be accepted, with >75% and >60% SB agreement required for first and second rounds, respectively. Results: There was a good response/completion rate for the initial (74%) and final (84%) voting rounds. The SB agreed on all 36 draft recommendations. The majority (n=34) were approved in the first round. Recommendations were organized according to the following categories: general approach to management (n=5), assessment (n=6), non-pharmacological (n=2) and pharmacological (n=10) management, endoscopic and surgical treatment (n=3), and special circumstances, including refractory GERD and SSc-ILD (n=3), myositis and SSc CTD-overlap (n=3) and peri-lung transplant (n=4). Conclusion: The group of experts has drafted extended and practical recommendations for the management of SSc refractory-GERD. The necessity of a structured approach and a patient assessment is highlighted in order to provide a multi-disciplinary approach to the tailored choice of the treatment. Our work also has also identified significant unmet needs and has provided a research agenda to advance the field.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Expert recommendations for the management of refractory gastro-oesophageal reflux disease in systemic sclerosis: a report from the World Scleroderma Foundation (WSF) Gastrointestinal ‘Ad hoc committee’
- Date Crossref
- 01/01/2026
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Manchester pays non établi dans la noticeUniversité ou école supérieure
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Northern Health and Social Care Trust pays non établi dans la noticeÉtablissement de santé
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NIHR Manchester Biomedical Research Centre pays non établi dans la noticeStructure de recherche
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Northern Care Alliance NHS Foundation Trust Department of Rheumatology pays non établi dans la noticeÉtablissement de santé
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University of Florence Department of Experimental and Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Hebron University Digestive System Research Unit pays non établi dans la noticeUniversité ou école supérieure
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Vall d'Hebron Hospital Universitari pays non établi dans la noticeÉtablissement de santé
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Stanford University Division of Gastroenterology and Hepatology pays non établi dans la noticeUniversité ou école supérieure
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Manchester University NHS Foundation Trust Department of Colorectal Surgery pays non établi dans la noticeÉtablissement de santé
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University College London Centre for Rheumatology and Connective Tissue Diseases pays non établi dans la noticeUniversité ou école supérieure
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Inserm pays non établi dans la noticeOrganisme public
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École des Hautes Études en Santé Publique pays non établi dans la noticeUniversité ou école supérieure
University of Manchester, Northern Health and Social Care Trust et NIHR Manchester Biomedical Research Centre, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.