Brady Bernard

A tailored in vivo CRISPR screen identifies BAP1 as a potent tumor suppressor of sarcoma

Jianguo Huang, Xingliang Liu, Warren Floyd, William Haugh et autres

Undifferentiated pleomorphic sarcoma (UPS) is one of the most common adult soft-tissue sarcomas (STSs), yet therapeutic progress remains limited because of the absence of recurrent oncogenic driver mutations. To identify tumor suppressors contributing to UPS pathogenesis, we performed a customized in vivo …

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Abstract LB425: Search for targets of anti-cancer immunity in patients receiving an off-the-shelf cancer’s dark matter vaccine, DPV-001, combined with anti-PD-1 +/- anti-GITR in head and neck squamous cell cancer (HNSCC)

Traci L. Hilton, Ryan Meng, Guo Hui Gan, Tarsem Moudgil et autres

Abstract Background: Despite advances in cancer genomics and immunotherapy, most cancer vaccine strategies target a limited set of canonical or mutated cancer antigens, capturing only a fraction of tumor antigenicity. Malignant cells generate a vast, largely unexplored repertoire of non-canonical “dark matter” …

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CMS subtypes correlate with complete response in trial of neoadjuvant Galunisertib plus chemoradiation in rectal cancer

Venkatesh Rajamanickam, Noah D. Simons, Wesley K. Rosales, Anton Kravchenko et autres

Improving responses to neoadjuvant therapy for patients with locally advanced rectal cancer has the potential to improve organ preservation and disease-free survival. Knowing which patients may need therapeutic escalation or de-escalation from standard-of-care treatment remains an area of investigation. We previously reported …

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The Immune Landscape of Cancer

Vésteinn Thórsson, Vésteinn Thorsson, David L. Gibbs, Scott D. Brown et autres

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-characterized by …

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Comprehensive molecular characterization of urothelial bladder carcinoma

John N. Weinstein, Rehan Akbani, Bradley McIntosh Broom, Wenyi Wang et autres

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents have been approved for treatment of the disease. As part of The Cancer Genome Atlas project, we report here …

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Knowledge-based design of inorganic-binding peptides

Brady Bernard, Ram Samudrala, Mehmet Sarıkaya, Candan Tamerler et autres