Hongyu Li

Anoctamin 5 mutation leads to abnormal bone homeostasis of GDD by regulating AMPK-dependent glucose metabolism

Hongyu Li, Xu Han, Kaiwen Sun, Shengnan Wang et autres

Introduction Gnathodiaphyseal Dysplasia (GDD) characterized by enhanced bone mass and spontaneous fractures is a rare autosomal dominant genetic disease caused by Anoctamin 5 (ANO5) mutations. Deletion or mutation in ANO5 exhibited abnormal bone metabolism of GDD manifested by increased osteogenesis and reduced …

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data

Hongyu Li

data

Hongyu Li

Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury

Qi Liu, Borui Xue, Yongfeng Zhang, Mingze Qin et autres

Peripheral nerve injury causes muscle atrophy due to slow axonal regeneration, highlighting an unmet therapeutic need. Although neuromuscular interactions are classically viewed as unidirectionally nerve dominated, we show that acutely denervated muscle (adMu) regulates nerve regeneration via a retrograde signaling pathway. adMu …

cn (code pays fourni par la source)

LSSF: Safety Alignment for Large Language Models through Low-Rank Safety Subspace Fusion

Guanghao Zhou, Panjia Qiu, Cen Chen, Hongyu Li et autres

The safety mechanisms of large language models (LLMs) exhibit notable fragility, as even fine-tuning on datasets without harmful content may still undermine their safety capabilities. Meanwhile, existing safety alignment methods predominantly rely on the fine-tuning process, which inadvertently leads to the increased …

LSSF: Safety Alignment for Large Language Models through Low-Rank Safety Subspace Fusion

Guanghao Zhou, Panjia Qiu, Cen Chen, Hongyu Li et autres

The safety mechanisms of large language models (LLMs) exhibit notable fragility, as even fine-tuning on datasets without harmful content may still undermine their safety capabilities. Meanwhile, existing safety alignment methods predominantly rely on the fine-tuning process, which inadvertently leads to the increased …