Yi Hsiao

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets

Shih-Chun A. Chu, Yi Hsiao, Chenwei Wang, Jennifer E. Kyle et autres

Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous hematological malignancy. Here, to better define this clinically taxing and translationally challenging malignancy, we applied a multiomics approach, consisting of 13 modalities to analyze 173 treatment-naive individuals with AML. By integrating these …

us, my, pl (code pays fourni par la source)

Advancing Multi-Omics Analysis Through Proteomics-Centric Tools and Methods

Yi Hsiao

Proteomics—the comprehensive study of proteins—has become central to biomedical research, especially as it is increasingly integrated with other omics modalities such as transcriptomics, metabolomics, and post-translational modification profiling. This dissertation advances proteomics-centric multi-omics analysis through the development of novel computational tools and …