Accès ouvert
2026
article
OpenAlex
Yupeng Liu, Helen Donnelly, Alvaro Donayre, Erin Korth et autres
Rationale: Defining the microbial etiology of sepsis is difficult but has important implications for antibiotic stewardship and prognosis. We explore the diagnostic yield of a novel, direct-from-blood multiplex polymerase chain reaction in intensive care unit patients with suspected sepsis. Methods: From March …
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Accès ouvert
2026
article
OpenAlex
Adrian Valadez, Marc H Scheetz, Michael Neely, Helen K Donnelly et autres
BACKGROUND: Meropenem is widely used to treat hospital-acquired pneumonia in critically ill patients, with efficacy dependent on the time that free concentrations exceed the minimum inhibitory concentration (fT > MIC). In practice, single-sample therapeutic drug monitoring (TDM) may not ensure target attainment, …
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2026
article
OpenAlex
Arsalan Ahmad, Douglas Wiegmann, Oliver Nguyen, Joy Moy et autres
Introduction: Time-limited trials (TLT) are a flexible approach to decision-making about life-sustaining therapies amid uncertainty in critically ill patients. Though increasingly used in ICUs, their conduct varies widely and is shaped by clinician judgment and context. Amidst this wide variation in practice, …
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2026
article
OpenAlex
Andrew Wu, Cemre Orhan, Joy Moy, Emily Campbell et autres
Introduction: A time-limited trial (TLT) is a collaborative plan among patients, surrogates, and clinicians to try life-sustaining therapy for a defined duration for critically ill patients whose prognosis is uncertain. Prior work demonstrates variability in physicians’ use of TLTs, but little is …
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Accès ouvert
2026
article
OpenAlex
Adrian Valadez, Emma Harlan, Marc H. Scheetz, Helen K Donnelly et autres
Abstract Background The impact of continuous renal replacement therapy (CRRT) on cefepime (FEP) pharmacokinetics (PK) in the epithelial lining fluid (ELF) of patients with hospital-acquired pneumonia is not well described.Population PK parameters for FEP in Renal Replacement in Plasma and ELFObserved vs. …
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