Bayesian Dosing Simulator ( BDS ): A Pharmacokinetic Modeling Tool for Optimized Antibiotic Therapy
Adrian Valadez, Marc H Scheetz, Michael Noel Neely, Helen K Donnelly et autres
BACKGROUND: Meropenem is widely used to treat hospital-acquired pneumonia in critically ill patients, with efficacy dependent on the time that free concentrations exceed the minimum inhibitory concentration (fT > MIC). In practice, single-sample therapeutic drug monitoring (TDM) may not ensure target attainment, …
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Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy