Maria Llamazares-Prada

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

Kathleen Schlueter, Mei-Ju May Chen, Gizem Altun, Sergio Manzano-Sanchez et autres

Abstract Loss of the Y chromosome (LOY) is associated with poor survival across multiple solid tumors, yet the underlying molecular mechanisms remain poorly understood. Here, we identify LOY as a central driver of lineage plasticity and epigenetic heterogeneity in lung adenocarcinoma. Integrating …

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Abstract LB309: Y chromosome loss drives cellular plasticity through single-cell epigenetic and transcriptional heterogeneity in lung adenocarcinoma

Kathleen Schlüter, Mei-Ju May Chen, Gizem Altun, Sergio Manzano Sanchez et autres

Abstract Loss of the Y chromosome (LOY) is among the most frequent somatic alterations in the blood of aging men. In cancer, LOY is associated with poor survival across multiple solid entities, including non-small cell lung cancer. Yet, the molecular mechanisms linking …

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Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD

Maria Llamazares-Prada, Uwe Schwartz, Darius F. Pease, Stephanie T. Pohl et autres

Altered respiratory barrier integrity and impaired lung regeneration are hallmarks of chronic obstructive pulmonary disease (COPD). To investigate the molecular mechanisms driving the impaired regeneration of alveolar epithelial progenitors in COPD, we generated whole-genome DNA methylation and transcriptome maps of sorted human …

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Supplementary Figures from Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q

Etienne Sollier, Anna Riedel, Umut H. Toprak, Justyna A. Wierzbinska et autres

Supplementary Figure 1. Summary of the somatic alterations in the 39 ckAML samples. Supplementary Figure 2. Proportion of samples expressing the top pyjacker hits, for several AML cohorts profiled with RNA-seq. Supplementary Figure 3. Example rearrangements leading to gene activation and TP53 …

Supplementary Tables from Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q

Etienne Sollier, Anna Riedel, Umut H. Toprak, Justyna A. Wierzbinska et autres

ST1 Methods for enhancer hijacking detection ST2 Ranked and scored hematopoietic enhancers (based on ChIP-seq data for H3K27ac and P300 from K562, MOLM1 and Kasumi1) ST3 Pyjacker results for the 10 AML cell lines ST4 Pyjacker results for the 120 medulloblastoma samples …