Dania M. Méndez Cárdenas

2388-P: BMI-Dependent Impact of Type 1 Diabetes Genetic Risk on β-Cell Function at Disease Onset

Iryna Yurchenko, Christian Binsch, KATSIARYNA PRYSTUPA, Łukasz Szczerbiński et autres

Introduction and Objective: Genetic risk scores for type 1 diabetes (T1D), such as T1D-GRS2, are used for risk stratification, but it remains unclear if they also predict β-cell function (βCF) at disease onset. This study investigated using gold-standard measures, whether T1D-GRS2 is …

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2314-P: Dietary Pattern Associated with Increased Fasting C-Peptide Independent of Whole-Body Insulin Resistance

JULIA SCHWEINITZER, Kálmán Bódis, Volker Burkart, CHRISTIAN HERDER et autres

Introduction and Objective: Hyperinsulinemia is closely linked to insulin resistance (IR) and mostly considered as compensatory, yet evidence suggests primary hypersecretion can even precede and promote IR. We asked the question if specific dietary patterns are associated with whole-body IR-independent increases in …

1139-OR: Preserved Insulin Secretion Amplifies Metabolic Effects of Visceral Fat

Kálmán Bódis, ALEXANDRA CHADT, Christian Binsch, Iryna Yurchenko et autres

Introduction and Objective: Visceral adipose tissue (VAT) is a key driver of insulin resistance (IR), but it’s unclear if insulin secretory capacity modulates this link. It also remains an open question, if primary hyperinsulinemia—high β-cell output before dysglycemia—is permissive or causal for …

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Metabolic Factors Modulating the Connection between Diabetes and Pulmonary Alterations

Maurizio Di Marco, Kálmán Bódis, Zengbin Li, Dania M. Méndez Cárdenas et autres

Objective: Type 1 and 2 diabetes have been variably associated with reduced forced-expiratory-volume-in-1-second (FEV1) and forced-vital-capacity (FVC), but mechanisms remain unclear. This study examined the role of glucose and insulin metabolism for pulmonary function across diabetes (sub)types and normal glucose tolerance (CON) …

Metabolic Factors Modulating the Connection between Diabetes and Pulmonary Alterations

Maurizio Di Marco, Kálmán Bódis, Zengbin Li, Dania M. Méndez Cárdenas et autres

Objective: Type 1 and 2 diabetes have been variably associated with reduced forced-expiratory-volume-in-1-second (FEV1) and forced-vital-capacity (FVC), but mechanisms remain unclear. This study examined the role of glucose and insulin metabolism for pulmonary function across diabetes (sub)types and normal glucose tolerance (CON) …

Metabolic Factors Modulating the Connection Between Diabetes and Pulmonary Alterations

Maurizio Di Marco, Kálmán Bódis, Zengbin Li, Dania M. Méndez Cárdenas et autres

OBJECTIVE: Type 1 and 2 diabetes have been variably associated with reduced forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), but mechanisms remain unclear. This study examined the role of glucose and insulin metabolism for pulmonary function across …

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