Christian Binsch

Exercise Resistance in Obese Male NZO Mice Manifests as Local Muscle Remodelling Without Glycaemic Improvements

Christian Springer, Sebastian Sill, Christian Binsch, Taylor Schoen et autres

AIMS: Exercise improves glycaemic control, yet some individuals show limited benefit, termed exercise resistance. We investigated tissue-specific adaptations to chronic exercise in a polygenic model of obesity-driven type 2 diabetes (T2D). MATERIALS AND METHODS: Male New Zealand Obese (NZO) mice were fed …

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1205-OR: Tissue-Specific Mitochondrial Adaptations Parallel Metabolic Improvements after Bariatric Surgery

Kalliopi Pafili, KÁLMÁN B. BÓDIS, Christian Binsch, Lucia Mastrototaro et autres

Introduction and Objective: Humans with obesity-related insulin resistance (IR) and metabolic dysfunction-associated steatotic liver disease (MASLD) show different mitochondrial alterations. While oxidative phosphorylation (OXPHOS) can be increased in liver, it may be decreased in visceral (VAT), but neither in subcutaneous adipose tissue …

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2388-P: BMI-Dependent Impact of Type 1 Diabetes Genetic Risk on β-Cell Function at Disease Onset

Iryna Yurchenko, Christian Binsch, KATSIARYNA PRYSTUPA, Łukasz Szczerbiński et autres

Introduction and Objective: Genetic risk scores for type 1 diabetes (T1D), such as T1D-GRS2, are used for risk stratification, but it remains unclear if they also predict β-cell function (βCF) at disease onset. This study investigated using gold-standard measures, whether T1D-GRS2 is …

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1139-OR: Preserved Insulin Secretion Amplifies Metabolic Effects of Visceral Fat

Kálmán Bódis, ALEXANDRA CHADT, Christian Binsch, Iryna Yurchenko et autres

Introduction and Objective: Visceral adipose tissue (VAT) is a key driver of insulin resistance (IR), but it’s unclear if insulin secretory capacity modulates this link. It also remains an open question, if primary hyperinsulinemia—high β-cell output before dysglycemia—is permissive or causal for …

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2640-P: Role of Diabetes Subtypes for Reducing Modifiable Cardiovascular Risk Factors after Bariatric Surgery

Oana Patricia Zaharia, Christian Binsch, SANDRA TRENKAMP, Jennifer Pützer et autres

Introduction and Objective: Phenotype-based clustering uncovered diabetes heterogeneity, but its relevance for tailored treatment remains unclear. The severe insulin-resistant diabetes subtype (SIRD) associates with steatotic liver disease, and higher cardiovascular risk, while moderate obesity-related diabetes (MOD) features mild metabolic alterations despite similar …

Enhancing Type 1 Diabetes Polygenic Risk Prediction Through Neural Networks and Entropy-Derived Insights

Antonio Nadal-Martínez, Guillermo Pérez-Solero, Sandra Ferreiro López, Jorge Blom-Dahl et autres

Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component (~70% heritability). Early identification of individuals at risk is crucial for early intervention or risk assessment. Although polygenic risk scores (PRS) have shown promise in risk assessment, most current …

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PTA-DFS study: design of a randomised controlled trial assessing the effects of early percutaneous transluminal angioplasty on the healing of diabetic foot ulcers in persons with type 2 diabetes

Kálmán Bódis, David-Ioan Florea, Shouheng Goh, Nicolas Kramser et autres

BACKGROUND: Peripheral arterial disease (PAD) and local infections increase the risk of non-healing diabetic foot ulcers (DFU) and limb amputations but are treatable by percutaneous transluminal angioplasty (PTA), local wound care and antibiotic therapy. The exact time to treat chronic leg artery …

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Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes

Oana‐Patricia Zaharia, Yuliya Kupriyanova, Pavel Bobrov, Christian Binsch et autres

OBJECTIVE: The severe insulin-resistant diabetes (SIRD) endotype is associated with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD. RESEARCH DESIGN AND METHODS: Participants (N = 420) of the …

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Role of adipose tissue compartments for cardiovascular risk in diabetes endotypes

Oana‐Patricia Zaharia, Yuliya Kupriyanova, Pavel Bobrov, Christian Binsch et autres

Objective: The severe insulin-resistant diabetes (SIRD) endotype associates with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD. Research design and Methods: Participants (n=420) of the German Diabetes Study …

Role of adipose tissue compartments for cardiovascular risk in diabetes endotypes

Oana‐Patricia Zaharia, Yuliya Kupriyanova, Pavel Bobrov, Christian Binsch et autres

Objective: The severe insulin-resistant diabetes (SIRD) endotype associates with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD. Research design and Methods: Participants (n=420) of the German Diabetes Study …

438-P: Adipose-Tissue Insulin Resistance Predicts Mortality in Persons at Risk for Cardiac Diseases

Kálmán Bódis, Christian Binsch, KATSIARYNA PRYSTUPA, Oana‐Patricia Zaharia et autres

Introduction and Objective: Insulin resistance (IR) significantly contributes to cardiovascular mortality in type 2 diabetes (T2D). Whether organ-specific IR (skeletal muscle, adipose tissue, liver) independently associates with structural and functional cardiac morbidity and mortality is unclear. Methods: This study included 850 Europeans …

1372-P: Evaluation of Urinary C-Peptide as a Surrogate to Predict Subtypes in Adult-Onset Diabetes

TANMAY RAMESH LONDHE, Iryna Yurchenko, Christian Binsch, KATSIARYNA PRYSTUPA et autres

Introduction and Objective: Urinary C-peptide (UCP) could provide an easily measurable alternative to serum C-peptide (SCP). We aimed (i) to check over-time stability of UCP and (ii) to use UCP to predict homeostasis modelling assessment 2 indices of insulin resistance and beta …

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