Accès ouvert
2026
article
OpenAlex
Daniela T. Asenjo, Lynn Devilée, Aaron H. Wasserman, Sitthixai Vongdeuane et autres
Canonical Wnt/β-catenin pathway activation can promote cardiomyocyte (CM) cell cycle activity, but translation is limited by off-target and functional liabilities associated with global pathway activation. We identified two small molecules, LRN9 and DF6, which potentiate Wnt/β-catenin signaling through a non-GSK3β mechanism and …
us, au
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Sitthixai Vongdeuane, Daniela T. Fuller, Yijia Li, Wei Chao et autres
Introduction: Mammalian cardiomyocytes (CMs) transition from a proliferative fetal state to a terminally differentiated adult phenotype, which is crucial for heart maturation. The balance between proliferation and maturation is poorly understood. Our laboratory discovered that C5ORF51/RIMOC1 (C5x) plays an essential role in …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Daniela T. Fuller, Lynn Devilée, Sitthixai Vongdeuane, Leif R. Neitzel et autres
Introduction: Heart failure, which is one of the leading causes of death worldwide, is characterized by the irreversible loss of cardiomyocytes (CMs). Over the past few decades, there has been significant interest in exploring strategies to revive the inherent regenerative potential of …
us, au
(code pays fourni par la source)