Daniela T. Fuller

Cardiomyocyte Proliferation in Embryonic Zebrafish Hearts Induced by Novel Small-Molecule Compounds

Benjamin Xu, Daniela T. Fuller, Dalila Livadic, Aaron H. Wasserman et autres

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Insights into Cardiomyocyte Regeneration from Screening and Transcriptomics Approaches

Daniela T. Fuller, Aaron H. Wasserman, Ruya Liu

Human adult cardiomyocytes (CMs) have limited regenerative capacity, posing a significant challenge in restoring cardiac function following substantial CM loss due to an acute ischemic event or chronic hemodynamic overload. Nearly half of patients show no improvement in left ventricular ejection fraction …

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Abstract Thu007: C5ORF51/RIMOC1 is Required for Adult Cardiomyocyte Maturation and Quiescence

Sitthixai Vongdeuane, Daniela T. Fuller, Yijia Li, Wei Chao et autres

Introduction: Mammalian cardiomyocytes (CMs) transition from a proliferative fetal state to a terminally differentiated adult phenotype, which is crucial for heart maturation. The balance between proliferation and maturation is poorly understood. Our laboratory discovered that C5ORF51/RIMOC1 (C5x) plays an essential role in …

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Abstract Thu008: Novel Kinase Inhibitor Induces 2D and 3D organoid iPSC-Derived Cardiomyocyte Proliferation

Daniela T. Fuller, Lynn Devilée, Sitthixai Vongdeuane, Leif R. Neitzel et autres

Introduction: Heart failure, which is one of the leading causes of death worldwide, is characterized by the irreversible loss of cardiomyocytes (CMs). Over the past few decades, there has been significant interest in exploring strategies to revive the inherent regenerative potential of …

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Inhibition of GPR68 induces ferroptosis and radiosensitivity in diverse cancer cell types

Leif R. Neitzel, Daniela T. Fuller, Jessica L. Cornell, Samantha Rea et autres

Radioresistance is thought to be a major consequence of tumor milieu acidification resulting from the Warburg effect. Previously, using ogremorphin (OGM), a small molecule inhibitor of GPR68, an extracellular proton sensing receptor, we demonstrated that GPR68 is a key pro-survival pathway in …

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Inhibition of GPR68 kills glioblastoma in zebrafish xenograft models

Leif R. Neitzel, Daniela T. Fuller, Charles H. Williams, Charles C. Hong

OBJECTIVE: Inhibition and knockdown of GPR68 negatively affects glioblastoma cell survival in vitro by inducing ferroptosis. Herein, we aimed to demonstrate that inhibition of GPR68 reduces the survival of glioblastoma cells in vivo using two orthotopic larval xenograft models in Danio rerio, …

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Clonal Proliferation Within Smooth Muscle Cells in Unstable Human Atherosclerotic Lesions

Kenji Kawai, Atsushi Sakamoto, Michal Mokrý, Saikat Ghosh et autres

BACKGROUND: Studies in humans and mice using the expression of an X-linked gene or lineage tracing, respectively, have suggested that clones of smooth muscle cells (SMCs) exist in human atherosclerotic lesions but are limited by either spatial resolution or translatability of the …

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Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy

Young Wook Chun, Matthew Miyamoto, Charles H. Williams, Leif R. Neitzel et autres

Background: During cardiomyocyte maturation, the centrosome, which functions as a microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization where its components reorganize from being localized at the centriole to the nuclear envelope. This developmentally programmed process, referred to as centrosome reduction, …

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CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque

Atsushi Sakamoto, Rika Kawakami, Masayuki Mori, Liang Guo et autres

Vascular calcification (VC) is concomitant with atherosclerosis, yet it remains uncertain why rupture-prone high-risk plaques do not typically show extensive calcification. Intraplaque hemorrhage (IPH) deposits erythrocyte-derived cholesterol, enlarging the necrotic core and promoting high-risk plaque development. Pro-atherogenic CD163+ alternative macrophages engulf hemoglobin:haptoglobin …

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Genetic Variants Associated With Unexplained Sudden Cardiac Death in Adult White and African American Individuals

Liang Guo, Sho Torii, Raquel Fernandez, Ryan E. Braumann et autres

Importance: Unexplained sudden cardiac death (SCD) describes SCD with no cause identified. Genetic testing helps to diagnose inherited cardiac diseases in unexplained SCD; however, the associations between pathogenic or likely pathogenic (P/LP) variants of inherited cardiomyopathies (CMs) and arrhythmia syndromes and the …

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APOL1 Genetic Variants Are Associated With Increased Risk of Coronary Atherosclerotic Plaque Rupture in the Black Population

Anne Cornelissen, Daniela T. Fuller, Raquel Fernandez, Xiaoqing Zhao et autres

Objective: Reported associations between kidney risk variants (G1 and G2) in APOL1 (apolipoprotein L1), encoding APOL1, and cardiovascular disease have been conflicting. We sought to explore associations of APOL1 risk variants with cause of sudden death using the CVPath Sudden Death Autopsy …

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Vascular Response of a Polymer-Free Paclitaxel-Coated Stent (Zilver PTX) versus a Polymer-Coated Paclitaxel-Eluting Stent (Eluvia) in Healthy Swine Femoropopliteal Arteries

Atsushi Sakamoto, Sho Torii, Hiroyuki Jinnouchi, Daniela T. Fuller et autres

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