Studies toward the imidazolyl-quinolone core of the bromotyrosine-derived alkaloid ceratinadin B
Anasuya Ghorai, Xiaofeng Meng, Lesley A. Schmid, Evans Fosu et autres
A de novo synthesis of the imidazolyl quinolone core of the marine sponge-derived alkaloid ceratinadin B was developed from 1,4-dimethoxybenzene. An acid mediated Friedel-Crafts reaction of a γ-aminobutyric acid derivative provided an aryl ketone which after bromination gave rise to the 2-aminoimidazole …
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