Hanshuang Cai

Discovery of Potent EGFR Inhibitors for Del19 and L858R / T790M Mutants Through Structure‐Based Virtual Screening and Biological Evaluation

Ting Xu, Yuchen Zhao, Mengfei Chen, Lijuan Zuo et autres

ABSTRACT Epidermal growth factor receptor (EGFR) mutation‐mediated drug resistance represents a major clinical challenge in the treatment of non‐small cell lung cancer (NSCLC). In this study, the lead compound XJ2‐2 was identified through structure‐based virtual screening. It exhibited potent anti‐proliferative activity against …

cn (code pays fourni par la source)

Design, synthesis, and antitumor evaluation of celastrol derivatives targeting PRDX3

Yuchen Zhao, Hanshuang Cai, Lijuan Zuo, Ting Xu et autres

cn (code pays fourni par la source)

SphK Inhibitor ZFP-B34 Suppresses the Growth of TNBC Cells

Bingqing Cui, Jianming Wei, Huiting Peng, Ting Xu et autres

Sphingosine kinase 1/2 (SphK1/2) promote the initiation and advancement of breast cancers. We performed screening on a compound library of SphK inhibitors using computer molecular docking and selected the most representative compound, ZFP-B34, for testing its antitumor activity in triple-negative breast cancer …

cn (code pays fourni par la source)