Sonia Francoeur

WCN26-8824 INFLAMMATION, TISSUE DAMAGE AND METABOLIC DEREGULATION IN A MOUSE MODEL OF MILD SEPSIS-RELATED ACUTE KIDNEY INJURY: TOWARDS THE DEVELOPMENT OF NEW DIAGNOSTIC AND THERAPEUTIC STRATEGIES

Emma Cavarocchi, Sonia Francoeur, Jean-Philippe C. Lavoie, Christine Légaré et autres

ca (code pays fourni par la source)

WCN26-8769 PROTECTIVE EFFECT OF P2Y14 RECEPTOR INHIBITION IN ISCHEMIA-INDUCED ACUTE KIDNEY INJURY: TOWARD THE DEVELOPMENT OF A NOVEL THERAPEUTIC STRATEGY

Jean-Philippe C. Lavoie, Christine Légaré, Sonia Francoeur, Emma Cavarocchi et autres

Ischemia-induced acute kidney injury (AKI) affects up to 50% of cardiac surgery (CS) patients, yet early diagnostic biomarkers and targeted therapies remain elusive. We previously showed that P2Y14 receptor inhibition attenuates AKI in male mice. P2Y14 is activated by UDP-sugars. Here, we …

ca, us (code pays fourni par la source)

Susceptibility of both female and male mice to acute kidney injury (AKI): protective effect of P2Y14 receptor inhibition

Jean-Philippe C. Lavoie, Christine Légaré, Sonia Francoeur, Sylvie Breton

While sex is increasingly considered as a critical variable in kidney health, female mice and patients remain underrepresented in preclinical and clinical studies. Ischemic-induced AKI is a frequent complication in hospitalized patients. Here, we assessed the severity of AKI in female and …

ca (code pays fourni par la source)