Sylvie Breton

Supplemental Figs S1-S4

Sylvie Breton

Supplementary figures for Légaré et al. AJP-Heart and Circulatory Physiology

Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients

Christine Légaré, Patrick Caron, Mohammad M. Al‐bataineh, Aisha Ford et autres

Acute kidney injury (AKI) is common in patients with open-heart surgery, but early diagnostics and therapies are limited. This study identifies a proinflammatory pathway activated during cardiopulmonary bypass. UDP-sugars are ligands of the P2Y14 receptor that appear during surgery in the urine …

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Supplemental Figs S1-S4

Sylvie Breton

Supplementary figures for Légaré et al. AJP-Heart and Circulatory Physiology

Supplemental Figs S1-S4

Sylvie Breton

Supplementary figures for Légaré et al. AJP-Heart and Circulatory Physiology

WCN26-8824 INFLAMMATION, TISSUE DAMAGE AND METABOLIC DEREGULATION IN A MOUSE MODEL OF MILD SEPSIS-RELATED ACUTE KIDNEY INJURY: TOWARDS THE DEVELOPMENT OF NEW DIAGNOSTIC AND THERAPEUTIC STRATEGIES

Emma Cavarocchi, Sonia Francoeur, Jean-Philippe C. Lavoie, Christine Légaré et autres

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WCN26-8769 PROTECTIVE EFFECT OF P2Y14 RECEPTOR INHIBITION IN ISCHEMIA-INDUCED ACUTE KIDNEY INJURY: TOWARD THE DEVELOPMENT OF A NOVEL THERAPEUTIC STRATEGY

Jean-Philippe C. Lavoie, Christine Légaré, Sonia Francoeur, Emma Cavarocchi et autres

Ischemia-induced acute kidney injury (AKI) affects up to 50% of cardiac surgery (CS) patients, yet early diagnostic biomarkers and targeted therapies remain elusive. We previously showed that P2Y14 receptor inhibition attenuates AKI in male mice. P2Y14 is activated by UDP-sugars. Here, we …

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Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology

Forough Chelangarimiyandoab, Jean-Philippe C. Lavoie, Nicolas Flamand, Emmanuelle Cordat et autres

Inflammation is a critical immune response to tissue injury or infection, involving a cascade of molecular and cellular events. This review examines acute inflammation, focusing on the key receptors, signaling pathways, mediators, and cellular players involved in the response throughout the body. …

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Susceptibility of both female and male mice to acute kidney injury (AKI): protective effect of P2Y14 receptor inhibition

Jean-Philippe C. Lavoie, Christine Légaré, Sonia Francoeur, Sylvie Breton

While sex is increasingly considered as a critical variable in kidney health, female mice and patients remain underrepresented in preclinical and clinical studies. Ischemic-induced AKI is a frequent complication in hospitalized patients. Here, we assessed the severity of AKI in female and …

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Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis

Kéliane Brochu, Aram Minas, Larissa Berloffa Belardin, Christine Légaré et autres

Extracellular adenosine triphosphate (ATP) is a signaling molecule that acts as a paracrine and autocrine modulator of cell function. Here, we characterized the role of luminal ATP in the regulation of epithelial principal cells (PCs) in the epididymis, an understudied organ that …

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Regulation of NHE3 subcellular localization in epididymal principal cells: pH, cyclic adenosine 3,5 monophosphate (cAMP), and adenosine signaling

Larissa Berloffa Belardin, Kéliane Brochu, Christine Légaré, Sylvie Breton

INTRODUCTION: The epididymis creates an optimal acidic luminal environment for sperm maturation and storage. In epididymal principal cells (PCs), proton secretion is activated by the accumulation of the sodium-proton exchanger type 3, NHE3 (SLC9A3), in apical stereocilia. PCs also secrete ATP, which …

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Uridine Diphosphate (UDP) Sugars Predict AKI in Cardiac Surgery Patients

Christine Légaré, Patrick Caron, Chantal Guillemette, Siamak Mohammadi et autres

Background: UDP-sugars including UDP-glucose (UDP-Glc), UDP-galactose (UDP-Gal), UDP-N-acetylgalactosamine (UDP-GalNAc), UDP-N-acetylglucosamine (UDP-GlcNAc), and UDP-glucuronic acid (UDP-GlcA) activate the pro-inflammatory P2Y14 receptor. Previously, we showed elevated urine UDP-Glc in intensive care unit patients with AKI compared to those without AKI. In addition, renal ischemia …

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Chimeras Derived from a P2Y14 Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation

Zhiwei Wen, Asmita Pramanik, Sarah A. Lewicki, Kwan‐Young Jung et autres

Tethered glycoconjugates of a naphthalene- and piperidine-containing antagonist of the P2Y 14 receptor (PPTN) were synthesized, and their nM receptor binding affinity was determined using a fluorescent tracer in hP2Y 14 R-expressing whole CHO cells. The rationale for preparing mono- and disaccharide …

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