Dana Venkert

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk (Adv. Healthcare Mater. 1/2026)

Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky et autres

3D Cancer Models This illustration presents a schematic construction site where tumor masses are built as avatars composed of cancer, immune, stromal cells, and blood vessels. Tools and machines represent advanced 3D technologies, while a truck delivers bacteria to model tumor-microbiome crosstalk, …

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky et autres

The tumor microenvironment (TME) is a complex and dynamic ecosystem increasingly recognized for its interplay with the microbiome. In colorectal, breast, lung, liver, and brain cancers, bacterial communities and their metabolites are shown to influence tumor progression, immune responses, and therapeutic outcomes. …

il (code pays fourni par la source)

Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via immunotherapy

Rami Khoury, Giuseppe Longobardi, Tania Barnatan, Dana Venkert et autres

Poly (ADP-ribose) polymerase inhibitors (PARPi) have revolutionized the treatment landscape for patients suffering from BRCA1- mutated breast and ovarian cancers. However, responses are not durable. We demonstrate that treatment with the PARPi, niraparib, increases programmed cell death protein-1 ligand (PD-L1) expression in …

il, us, pt (code pays fourni par la source)