Jones Addiah-Nickson

Discovery of Small Molecule Ligands Targeting Orphan G Protein-Coupled Receptors GPR3, GPR6, and GPR12

Xiaochen Tian, Saghir Ali, Jones Addiah-Nickson, Haiying Chen et autres

GPR3, GPR6, and GPR12 form a subfamily of Class A orphan G protein-coupled receptors (oGPCRs), for which endogenous ligands have not been identified. Despite their high sequence similarity, each receptor exhibits unique expression profiles in human tissues. Their physiological roles and therapeutic …

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Structure-Function Mechanisms for Brain Orphan Receptor GPR6 Constitutive Activity and Inverse Agonism (Abstract ID: 231050)

Jones Addiah-Nickson, John Allen

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Probing chemical space and conformational changes for subtype-selective orexin receptor antagonists

Hudson R. Smith, Elizabeth Saab, Cadell Green, Jones Addiah-Nickson et autres

signaling). Given the close interplay among the orexin, dopamine and opioid systems in reward and motivation pathways, herein we further highlight the compatibility of dopaminergic and opioid-related scaffolds in expanding the chemical space for OXR ligand design.

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GPR52 Constitutively Activates Multiple G Proteins and Beta-Arrestin2: Insights for Orphan GPCR Signaling (Abstract ID: 167613)

Jones Addiah-Nickson, Ryan E. Murphy, John Allen

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Characterization of Receptor and Ligand-Mediated Signaling Mechanisms for GPR37: A Novel Target for Treating Pain and Neurological Disorders (Abstract ID: 190876)

H. Clay Smith, Jones Addiah-Nickson, Andrew Frazier, John Allen

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