John Allen

Cytokine dysregulation in children with severe neurological impairment correlates with significant clinical outcomes

John Allen, Johana M. Isaza-Correa, Lynne A. Kelly, Ashanty M. Melo et autres

Background Children with neurological disorders have altered inflammatory responses. We aimed to describe pro-inflammatory, anti-inflammatory and hypoxia-induced cytokines in serum, at baseline, and in response to stimulation of whole blood with lipopolysaccharide, in children with Severe Neurological Impairment (SNI) compared to controls. …

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Clinical heterogeneity of adolescents referred to paediatric palliative care; a quantitative observational study

Hannah Linane, John Allen, Mary Devins, Marie Twomey et autres

OBJECTIVES: Adolescents with life-limiting conditions are distinct from children or older adults in their palliative needs and developmental stage, yet, there is limited literature addressing this population. Our aim was to describe the characteristics of the adolescent population, aged 13-18, who have …

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Regulation of heterotrimeric G protein signaling by lipid microdomains.

John Allen

Regulation of heterotrimeric G protein signaling by lipid microdomains.

GPR52 Constitutively Activates Multiple G Proteins and Beta-Arrestin2: Insights for Orphan GPCR Signaling (Abstract ID: 167613)

Jones Addiah-Nickson, Ryan E. Murphy, John Allen

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ECL2 Mechanism for Brain Orphan Receptor GPR52 Signaling and Virtual Screening to Discover Novel Agonists (Abstract ID: 163948)

H. Clay Smith, Ryan E. Murphy, John Allen

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Characterization of Receptor and Ligand-Mediated Signaling Mechanisms for GPR37: A Novel Target for Treating Pain and Neurological Disorders (Abstract ID: 190876)

H. Clay Smith, Jones Addiah-Nickson, Andrew Frazier, John Allen

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Correction: Neonatal sepsis definitions from randomised clinical trials

Rían Hayes, Jack Hartnett, Gergana Semova, Cian Murray et autres

Appendix 1 , which is mentioned in the text, was unfortunately missing from the original version and it has now been added. The original article has been corrected.

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Discovery of 3-((4-Benzylpyridin-2-yl)amino)benzamides as Potent GPR52 G Protein-Biased Agonists

Ryan E. Murphy, Pingyuan Wang, Saghir Ali, Hudson R. Smith et autres

Orphan GPR52 is emerging as a promising neurotherapeutic target. Optimization of previously reported lead 4a employing an iterative drug design strategy led to the identification of a series of unique GPR52 agonists, such as 10a ( PW0677 ), 15b ( PW0729 ), …

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Pragmatism and power, or the power to make a difference in a radically contingent world

John Allen

Power seems to occupy an understated role in much pragmatist thought, both classical and contemporary. It is clearly a blind spot in Richard Rorty’s work, although ever present in the background, and for John Dewey and William James, it often appears as …

Power's quiet reach

John Allen

Topological shifts in the spacing and timing of relationships have enabled governments, institutional authorities and other powerful bodies to reach into people’s lives through quieter, more muted, means that are often unrecognizable as expressions of power. The ability to establish relational proximities …

Power and Space

John Allen

Power and Space sets out the inherently spatial nature of power today and seeks to change the conversation around how power exercises us in the contemporary moment. The essays brought together in this book are a response to the fact that conventional …

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Topological twists

John Allen

The pervasive quality of governments to reach directly into our lives, the striking ability of far-flung corporations to make their presence felt at close quarters, and the ease with which NGOs fold distant harms into local campaigns all speak to a world …