Accès ouvert
2026
conference-abstract
OpenAlex
Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B. Hoelscher et autres
Abstract Rising incidence of early-onset prostate and other solid tumors underscores the need for experimental systems that model how normal tissues traverse premalignant states, acquire mutations, and become therapy-responsive malignancies under authentic immune and stromal pressures. A major barrier has been the …
us, ch
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B. Hoelscher et autres
Abstract Rising incidence of early-onset cancers demands experimental systems that model how normal tissues traverse premalignant states to form clinically relevant, therapy-responsive tumors, and how host immunity and ancestry-linked genetics shape that trajectory. A major obstacle has been the lack of tractable …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B. Hoelscher et autres
Interrogating the stochastic events underlying tumor evolution from non-malignant precursors is crucial for understanding therapy resistance. Current methods are complicated by chromosomal instability, obscuring driver identification and yielding non-representative genetics. Inspired by patient tumors that evolve without chromosomal instability, we developed Stochastically …
us, ch
(code pays fourni par la source)