Matthew J. Ryan

Abstract A008: Reconstructing prostate evolution with Stochastically Emergent Tumors (SETs) reveals in vivo therapeutic vulnerabilities

Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B. Hoelscher et autres

Abstract Rising incidence of early-onset prostate and other solid tumors underscores the need for experimental systems that model how normal tissues traverse premalignant states, acquire mutations, and become therapy-responsive malignancies under authentic immune and stromal pressures. A major barrier has been the …

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Assessing competence in unsedated transnasal endoscopy: Development of the TransNasal Endoscopy Skills Assessment Tool

Lisa B. Mahoney, Jenifer R. Lightdale, Eitan Rubinstein, Nicholas Carman et autres

OBJECTIVES: Despite the growing use of unsedated transnasal endoscopy (uTNE) in pediatrics, no validated tool exists to assess competence in performing uTNE, hindering effective training and consistent, high-quality performance. Video-based assessment offers a scalable and reliable method for assessing and enhancing procedural …

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Abstract IA006: Reconstructing evolution with Stochastically Emergent Tumors (SETs) reveals in vivo vulnerabilities

Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B. Hoelscher et autres

Abstract Rising incidence of early-onset cancers demands experimental systems that model how normal tissues traverse premalignant states to form clinically relevant, therapy-responsive tumors, and how host immunity and ancestry-linked genetics shape that trajectory. A major obstacle has been the lack of tractable …

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Incidence of tracheal stenosis following tracheostomy, does the surgical technique matter?

Matthew J. Ryan

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The mouth or the nose: the past, present, and future of ultra-slim gastroscopy of the upper gastrointestinal tract in pediatrics

Rose Lee, Ali Mencin, Matthew J. Ryan, Joel A. Friedlander et autres

Background: Ultra-slim, flexible endoscopy pioneered for the evaluation of luminal diseases of the airway, has been used for over 40 years. In the late 20th century, it was adopted in the gastrointestinal specialties for evaluation of the digestive tract with and without …

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Gastroesophageal reflux during postpyloric versus gastric tube feeding in preterm infants with bronchopulmonary dysplasia

Erik A. Jensen, Carolyn M. Orians, Kathleen Gibbs, Matthew J. Ryan

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Stochastically Emergent Tumors offer in vivo whole genome interrogation of cancer evolution from non-malignant precursors

Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B. Hoelscher et autres

Interrogating the stochastic events underlying tumor evolution from non-malignant precursors is crucial for understanding therapy resistance. Current methods are complicated by chromosomal instability, obscuring driver identification and yielding non-representative genetics. Inspired by patient tumors that evolve without chromosomal instability, we developed Stochastically …

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S679 Efficacy of Dupilumab on Facilitated Food Introduction in Eosinophilic Esophagitis

Nicole Wolfset, Amanda Miur, Terri Faye Brown-Whitehorn, Melanie A. Ruffner et autres

Introduction: Eosinophilic esophagitis (EoE) is a chronic, debilitating disease characterized by esophageal inflammation, eosinophilic infiltration, and dysphagia. Common foods like milk, egg, soy, and wheat often trigger EoE. Treatments include dietary avoidance, dupilumab, and off-label use of swallowed steroids or proton-pump-inhibitors. However, …

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Sa1263 ENDOSCOPIC AND HISTOLOGIC UTILITY OF TRANSNASAL ENDOSCOPY IN PEDIATRIC EOSINOPHILIC ESOPHAGITIS

Kanak V. Kennedy, Eliana Shaul, Zachary C. Spergel, Shanaz Daneshdoost et autres

Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis

Eliana Shaul, Kanak V. Kennedy, Zachary C. Spergel, Shanaz Daneshdoost et autres

Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis …

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Elucidating ion configurations and water dynamics in a K+ ion channel using two-dimensional infrared spectroscopy

Alexei A. Kananenka, Matthew J. Ryan, Lujia Gao, Francis I. Valiyaveetil et autres

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Molecular dynamics simulation study of water structure and dynamics on the gold electrode surface with adsorbed 4-mercaptobenzonitrile

Kijeong Kwac, Nan Yang, Matthew J. Ryan, Martin T. Zanni et autres

Understanding water dynamics at charged interfaces is of great importance in various fields, such as catalysis, biomedical processes, and solar cell materials. In this study, we implemented molecular dynamics simulations of a system of pure water interfaced with Au electrodes, on one …

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