Accès ouvert
2026
article
OpenAlex
Viola Bianca Serio, Tommaso Regoli, Elisa Frullanti, Maria Palmieri
Background: While Immune Checkpoint Inhibitors (ICIs) have significantly improved outcomes in lung cancer (LC), clinical responses remain heterogeneous. Static tissue biomarkers, like PD-L1, and tumor mutational burden (TMB) are limited by intratumoral heterogeneity and the inability to track temporal changes. This review …
it
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Accès ouvert
2026
article
OpenAlex
Kateryna Miedviedieva, Tommaso Regoli, Stefania Marchisotta, L. Sessa et autres
Background/Objectives: Obesity is a global health emergency with a complex etiology, in which monogenic forms, although rare, are significantly underdiagnosed. In our clinical setting, first-tier genetic screening panels targeting LEP, LEPR, BDNF, FTO, and MC4R often fail to identify a causative variant, …
it
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Accès ouvert
2026
article
OpenAlex
Viola Bianca Serio, Tommaso Regoli, Debora Maffeo, Ignazio Martellucci et autres
Programmed death-ligand 1 (PD-L1) expression is routinely used to guide immune checkpoint inhibitor (ICI) therapy in advanced non-small cell lung cancer (NSCLC), yet clinical benefit remains heterogeneous even among PD-L1–high tumors. Liquid biopsy based on cell-free DNA (cfDNA) enables minimally invasive, real-time …
it
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Accès ouvert
2025
article
OpenAlex
Enxhi Shaba, Claudia Ricci, Lorenza Vantaggiato, Maria Francesca Paolocci et autres
Ischemia/reperfusion injury (IRI) is a common damage due to the restoration of blood flow following an ischemic injury. Its pathogenesis is mainly linked to the production of reactive oxygen species (ROS), which sustain cell damage and promote cell death. The tardigrade damage …
it
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Accès ouvert
2025
article
OpenAlex
Silvia Cantara, Tommaso Regoli, Claudia Ricci
Tardigrades, also known as “water bears”, are microscopic invertebrates capable of surviving extreme conditions, including extreme temperatures, intense radiation, and the vacuum of space. Recent studies have unveiled a novel nucleosome-binding protein in the tardigrade Ramazzottius varieornatus, known as the damage suppressor …
it
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Accès ouvert
2025
preprint
OpenAlex
Silvia Cantara, Tommaso Regoli, Claudia Ricci
Tardigrades, also known as "water bears," are microscopic invertebrates capable of surviving extreme conditions, including extreme temperatures, intense radiation, and the vacuum of space. Recent studies have unveiled a novel nucleosome-binding protein in the tardigrade Ramazzottius varieornatus, known as the damage suppressor …
it
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Accès ouvert
2025
article
OpenAlex
Claudia Ricci, Annalisa Bufano, Gabriele Iraci Sareri, Maria Simon Batzibal et autres
Obesity is a global epidemic associated with chronic inflammation, oxidative stress, and metabolic disorders. Bariatric surgery is a highly effective intervention for sustained weight loss and the improvement of obesity-related comorbidities. However, post-surgery nutritional deficiencies, including vitamin E, remain a concern. This …
it
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