Silvia Cantara

Network based approach identifies miR ‐145‐3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma

Anna Citarella, Manuela Petti, Zein Mersini Besharat, Caterina Alfano et autres

Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor originating from calcitonin producing C-cells and accounts for 1-5% of thyroid cancers. Total thyroidectomy is curative in localized disease (N0), whereas lymph node metastases (N1) are associated with poorer prognosis. However, the molecular mechanisms …

it (code pays fourni par la source)

The Necessity of POMC and MC3R Analysis in the First-Level Diagnosis of Monogenic Obesity: The Experience of Two Italian Centers

Kateryna Miedviedieva, Tommaso Regoli, Stefania Marchisotta, L. Sessa et autres

Background/Objectives: Obesity is a global health emergency with a complex etiology, in which monogenic forms, although rare, are significantly underdiagnosed. In our clinical setting, first-tier genetic screening panels targeting LEP, LEPR, BDNF, FTO, and MC4R often fail to identify a causative variant, …

it (code pays fourni par la source)

Special Issue “Cancer Biology: From Genetic Aspects to Treatment: 1st Edition”

Silvia Cantara

The first documented description of cancer dates to ancient Egypt in around 1600 BCE and can be found in the Edwin Smith Papyrus [...].

it (code pays fourni par la source)

Investigating the Cytoprotective Mechanisms of the Tardigrade Damage Suppressor (Dsup) Protein in Human Cells Under Hypoxic Stress

Enxhi Shaba, Claudia Ricci, Lorenza Vantaggiato, Maria Francesca Paolocci et autres

Ischemia/reperfusion injury (IRI) is a common damage due to the restoration of blood flow following an ischemic injury. Its pathogenesis is mainly linked to the production of reactive oxygen species (ROS), which sustain cell damage and promote cell death. The tardigrade damage …

it (code pays fourni par la source)

Sex Hormone Profiles in Patients With Torsades de Pointes Ventricular Tachycardia

Pietro Enea Lazzerini, Vamsi Krishna Murthy Ginjupalli, Jean‐Baptiste Reisqs, Iacopo Bertolozzi et autres

BACKGROUND: Female sex is a well-recognized risk factor for long QT syndrome and torsades de pointes (TdP), likely reflecting the influence of sex hormones on ventricular repolarization. Overall, estradiol prolongs, whereas progesterone and testosterone shorten, heart rate-corrected QT interval. However, no studies …

it, us (code pays fourni par la source)

Captain Tardigrade and Its Shield to Protect DNA

Silvia Cantara, Tommaso Regoli, Claudia Ricci

Tardigrades, also known as “water bears”, are microscopic invertebrates capable of surviving extreme conditions, including extreme temperatures, intense radiation, and the vacuum of space. Recent studies have unveiled a novel nucleosome-binding protein in the tardigrade Ramazzottius varieornatus, known as the damage suppressor …

it (code pays fourni par la source)

Diagnostic Performance of Next-Generation Sequencing (NGS) in Indeterminate Thyroid Nodules: A Single Hospital Experience

Marco Capezzone, Maja Rossi, Sara Bardi, Eugenia Maria Morabito et autres

Fine-needle aspiration cytology (FNAC) is the gold standard to diagnose thyroid nodules but fails in discriminating the nature of indeterminate lesions. Molecular testing can improve the diagnosis of these nodules and next-generation sequencing (NGS) can be used to test many genes simultaneously. …

it (code pays fourni par la source)

Captain Tardigrade and Its Shield to Protect DNA

Silvia Cantara, Tommaso Regoli, Claudia Ricci

Tardigrades, also known as "water bears," are microscopic invertebrates capable of surviving extreme conditions, including extreme temperatures, intense radiation, and the vacuum of space. Recent studies have unveiled a novel nucleosome-binding protein in the tardigrade Ramazzottius varieornatus, known as the damage suppressor …

it (code pays fourni par la source)

Impact of Genetic Variants on Vitamin E Levels in an Italian Cohort of Bariatric Surgery Patients: A Focus on SNPs Involved with Transport and Bioavailability

Claudia Ricci, Annalisa Bufano, Gabriele Iraci Sareri, Maria Simon Batzibal et autres

Obesity is a global epidemic associated with chronic inflammation, oxidative stress, and metabolic disorders. Bariatric surgery is a highly effective intervention for sustained weight loss and the improvement of obesity-related comorbidities. However, post-surgery nutritional deficiencies, including vitamin E, remain a concern. This …

it (code pays fourni par la source)

HLA class I expression on human platelets is highly variable and correlates with distinct allele group frequencies.

Rocco Cantisani, Valeria Del Re, Francesca Toraldo, Silvia Cantara et autres

BACKGROUND: Human leukocyte antigen (HLA) class I molecules are expressed on platelets and can represent a source of alloimmunization in recipients of platelet transfusions. HLA mismatch between donors and recipients may be associated with the induction of anti-HLA antibodies, which can culminate …

it (code pays fourni par la source)

Usefulness of metabolomic analyses in the pre surgical evaluation of thyroid nodules

Fabio Maino, Silvia Cantara, Elisa Mattii, Daniela Grasso et autres

Paradoxical effect of dopamine-agonists on IGF-1 in patients with prolactinoma: the role of weight

Sonia Caprio, Tania Pilli, Silvia Cantara, Fausta Sestini et autres

PURPOSE: An increase of IGF-1 has been reported during therapy with dopamine agonists (DA) for prolactinomas; in such cases a correct diagnosis is pivotal to avoid an unnecessary reduction or withdrawal of DA, which are needed to maintain normal prolactin levels. This …

it (code pays fourni par la source)