Daniel Gimenes

Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops

Paul K. Wallace, Evan R. Jellison, Sherry Thornton, Kathleen Kluepfel et autres

joint effort begun in 2018 and continued in 2019 by Kamila Czechowska proved to be a valuable reference [1,2].Building on that spirit, we present summaries from CYTO 2025, held in Denver, Colorado, from May 31 to June 4.This manuscript serves as a …

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Cyt‐Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops

Paul K. Wallace, Evan R. Jellison, Sherry Thornton, Kathleen Kluepfel et autres

joint effort begun in 2018 and continued in 2019 by Kamila Czechowska proved to be a valuable reference [1,2].Building on that spirit, we present summaries from CYTO 2025, held in Denver, Colorado, from May 31 to June 4.This manuscript serves as a …

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Abstract P3-02-03: HEPARANASE LIQUID BIOPSY AND BREAST CANCER

Daniel Gimenes, Gislaine Patricia Andrade, Afonso Celso Pinto Nazário, Maria Aparecida da Silva Pinhal

Abstract Background: Breast cancer is a complex disease with high clinical and genetic heterogeneity and represents a public health problem worldwide, as it is among the four main causes of premature death in most countries. The molecular profile of solid tumors may …

Real-world validation of outcomes with adjuvant paclitaxel + trastuzumab (APT) in low-risk early-stage HER2 positive breast cancer

Christopher Lucas Negrete, Rafael Duarte Paes, Aline Coelho Gonçalves, Rafael Brant Costa et autres

Abstract 183: High-content screening reveals kinase regulators of Dvl2 phase separation in Wnt signaling: Implications for targeted cancer therapy

Antonia Schubert, Florian Heigwer, Christian Scheeder, Oksana Voloshanenko et autres

Abstract Wnt signaling controls cell proliferation, differentiation, and migration, with critical roles in diseases such as cancer. It was proposed that Wnt signaling relies on the formation of dynamic biomolecular condensates, such as the “signalosome” and the “destruction complex”, with a potential …

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Image-based screens identify regulators of endogenous Dvl2 biomolecular condensates

Antonia Schubert, Florian Heigwer, Christian Scheeder, Oksana Voloshanenko et autres

Summary Dishevelled (Dvl) proteins are essential transducers in Wnt signaling pathways, which have been implicated in development, stem cell maintenance, and human diseases such as cancer. Several studies have shown that Dvl proteins form dynamic biomolecular condensates. However, how cellular signals and …

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