Evan R. Jellison

Polarized release of brain microvascular endothelial cell- derived extracellular vesicles is functionally coupled to leukocyte transendothelial migration

Dylan Krajewski, Shujun Ge, Evan R. Jellison, Yi Wu et autres

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Endothelial Elavl1 Is Required for CD8 T-Cell Persistence in Atherosclerosis

Sarah-Anne E. Nicholas, Stephen B. Helming, Antoine Ménoret, Christopher L. Pathoulas et autres

BACKGROUND: Atherosclerotic plaques form through lipid and immune cell accumulation beneath the arterial endothelium. CD8 (cluster of differentiation 8) T cells are abundant in lesions, and their activation correlates with cardiovascular disease severity. Although endothelial cells recruit CD8 T cells to low …

Endothelial PTBP1 Deletion in Transplanted Cardiac Tissue Limits Cardiac Allograft Vasculopathy

Christopher L. Pathoulas, Koki Hayashi, Ivy A. Rosales, Amy L. Kimble et autres

Abstract Background Cardiac allograft vasculopathy (CAV) is a leading cause of late graft failure and mortality following heart transplantation, with limited therapeutic options. Endothelial cells (ECs), at the interface between the donor graft and host immune system, play a central role in …

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Harnessing the microbiome to regulate myeloid TREM2 expression and innate immune responses

Saki Mihori, Frank C. Nichols, Evan R. Jellison, Christopher N. Blesso et autres

The composition of the gastrointestinal microbiome is correlated with numerous immune-mediated systemic diseases, but underlying mechanisms remain unclear. In murine studies, we recently identified microbiome Bacteroidota-derived bacterial molecules, serine-glycine lipodipeptides (S/G lipids), as mediators of microbiome-systemic innate immune system crosstalk. By altering …

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Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops

Paul K. Wallace, Evan R. Jellison, Sherry Thornton, Kathleen Kluepfel et autres

joint effort begun in 2018 and continued in 2019 by Kamila Czechowska proved to be a valuable reference [1,2].Building on that spirit, we present summaries from CYTO 2025, held in Denver, Colorado, from May 31 to June 4.This manuscript serves as a …

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Cyt‐Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops

Paul K. Wallace, Evan R. Jellison, Sherry Thornton, Kathleen Kluepfel et autres

joint effort begun in 2018 and continued in 2019 by Kamila Czechowska proved to be a valuable reference [1,2].Building on that spirit, we present summaries from CYTO 2025, held in Denver, Colorado, from May 31 to June 4.This manuscript serves as a …

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Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects

Cheemala Ashok, Amy L. Kimble, Emily Burrage, Stephen B. Helming et autres

Mutations in the TARDBP gene encoding TDP-43 protein are linked to loss of function in neurons and familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We recently identified reduced nuclear TDP-43 in capillary endothelial cells (ECs) of donors with ALS-FTD. Because …

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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration

Omar M. Omar, Amy L. Kimble, Cheemala Ashok, Jordan D. Tyburski et autres

Endothelial cells (ECs) help maintain the blood-brain barrier but deteriorate in many neurodegenerative disorders. Here we show, using a specialized method to isolate EC and microglial nuclei from postmortem human cortex (92 donors, 50 male and 42 female, aged 20-98 years), that …

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TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units

Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue et autres

Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death. We reveal that TRPM2 expression in human peripheral leukocytes strongly …

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Verifying Proper Function of the Aerosol Evacuation System Prior to Sorting Potentially Infectious Samples

Kristen M. Reifel, Avrill Aspland, Suat Dervish, Iyadh Douagi et autres

High concentrations of aerosols can be generated within the sort collection area of cell sorters during instrument failures that cause the stream to deviate, such as a partial nozzle obstruction. Complete containment of these aerosol particles becomes essential for operator safety when …

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TRPM7 channel activity promotes the pathogenesis of abdominal aortic aneurysms

Pengyu Zong, Cindy X. Li, Jianlin Feng, Zhichao Yue et autres

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Astrocytes initiate autophagic flux and maintain cell viability after internalizing non-active native extracellular α-synuclein

Fotis Andromidas, Brooke MacKinnon, Abigail J. Myers, Melanie M. Shaffer et autres

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