Elaine Aparecida Del Bel

The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson’s Disease

Glauce Crivelaro Nascimento, Laurent Ferrié, Rita Raisman‐Vozari, Bruno Figadère et autres

br, fr (code pays fourni par la source)

Cannabigerol Attenuates Memory Impairments, Neurodegeneration, and Neuroinflammation Caused by Transient Global Cerebral Ischemia in Mice

Nathália Akemi Neves Kohara, Luís Fernando Fernandes Miranda, Pablo Pompeu Quini, Elaine Aparecida Del Bel et autres

Evidence supporting the clinical use of neuroprotective drugs for cerebral ischemia remains limited. Spatial and temporal disorientation, along with cognitive dysfunction, are among the most prominent long-term consequences of hippocampal neurodegeneration following cerebral ischemia. Cannabigerol (CBG), a non-psychotomimetic constituent of Cannabis sativa, …

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Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative

Bianca Andretto de Mattos, Rodrigo Hernán Tomas‐Grau, Thaís Antonia Alves Fernandes, Florencia González‐Lizárraga et autres

We aimed to simulate tau abnormalities-specifically hyperphosphorylation and aggregation-that are hallmarks of tauopathies, including Alzheimer's disease, to evaluate tau-targeting therapies. To model pathological p-tau accumulation at early disease stages, we exposed mouse cortical cultures to redox-active iron from hemin (Hm), a breakdown …

fr, br, ar, gp (code pays fourni par la source)

Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage

Aurore Tourville, Ismaïla Ciss, Rafaela Ribeiro Silva, Bianca Andretto de Mattos et autres

fr, br, us (code pays fourni par la source)

Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses

Ana Carolina Issy, João Francisco Cordeiro Pedrazzi, Glauce Crivelaro Nascimento, Lúcia Helena Faccioli et autres

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Experimental Periodontitis Worsens Dopaminergic Neuronal Degeneration

Gabrielle A. Jacob, Bruna Araujo Milan, Livia Rodrigues Antonieto, Yara Loyanne de Almeida Silva Levi et autres

AIM: To investigate the hypothesis supporting the link between periodontitis and dopaminergic neuron degeneration. MATERIALS AND METHODS: Adult male Wistar rats were used to induce dopaminergic neuronal injury with 6-hydroxydopamine (6-OHDA) neurotoxin and experimental periodontitis via ligature placement. Motor function assessments were …

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4′-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms

Maurício dos Santos Pereira, Gabriel H Dias de Abreu, Leonardo Calaça Arruda Vanderlei, Rita Raisman‐Vozari et autres

fr, br, us (code pays fourni par la source)

Differential dopamine-mediated effects in the 5-lipoxygenase deficient mice

Ana Carolina Issy, João Francisco Cordeiro Pedrazzi, Glauce Crivelaro Nascimento, Lúcia Helena Faccioli et autres

Abstract The role of 5-lipoxygenase/leukotrienes on the central nervous system has been considered in both physiological end pathological states. Investigating the interaction between 5-lipoxygenase/leukotrienes and the dopaminergic system may provide better understanding of dopamine-related pathologies. This study aimed to investigate motor and …

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Sodium nitroprusside enhances stepping test performance and increases medium spiny neurons responsiveness to cortical inputs in a rat model of Levodopa‐induced dyskinesias

Danilo Leandro Ribeiro, Rayanne Poletti Guimarães, Keila Bariotto‐dos‐Santos, Elaine Aparecida Del Bel et autres

Levodopa (L-DOPA) is the classical gold standard treatment for Parkinson's disease. However, its chronic administration can lead to the development of L-DOPA-induced dyskinesias (LIDs). Dysregulation of the nitric oxide-cyclic guanosine monophosphate pathway in striatal networks has been linked to deficits in corticostriatal …

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THE ROLE OF AN INTERACTION OF ENDOCANNABINOID, ENDOVANILLOID AND NITRERGIC SYSTEMS IN THE ANTIDYSKINETIC EFFECT OF CANNABIDIOL IN A RODENT MODEL OF PARKINSON’S DISEASE

Glauce Crivelaro Nascimento, Maurício dos Santos Pereira, Igor Gustavo Carvalho Oliveira, Maria Eugênia Costa Queiroz et autres

Pharmacological manipulation of the endocannabinoid system represents a promising therapy to alleviate (L-DOPA)-induced dyskinesia (LID) in Parkinson's disease. We tested, here, whether cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, and HUF-101, a fluorinated CBD derivative could improve LID. We were …

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CANNABIDIOL AND CANNABIGEROL LIMIT L-DOPA-INDUCED DYSKINESIA WHEN GIVEN SEPARATELY OR IN COMBINATION TO HEMIPARKINSONIAN RATS

Bianca Andretto de Mattos, Glauce Crivelaro Nascimento, José Alexandre S. Crippa, Jorge Hallak et autres

Cannabidiol (CBD) and Cannabigerol (CBG) are phytocannabinoids with multiple pharmacological effects of potential therapeutic properties, such as neuroprotective, anti-inflammatory, antioxidant, and anti-excitotoxic. These phytocannabinoids could also be a promising therapy to alleviate or prevent L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson’s disease (PD). …

br, fr (code pays fourni par la source)

Exploring cognitive and affective outcomes following bilateral 6-hydroxydopamine lesions of the substance nigra or striatum in rats

Bianca Andretto de Mattos, Jéssica Mendes Bonato, Elaine Aparecida Del Bel, Humberto Milani et autres

Abstract Purpose: The majority of animal models of Parkinson’s disease (PD) focus on motor symptoms that are induced by unilateral injections of such neurotoxins as 6-hydroxydopamine (6-OHDA) in nigrostriatal dopaminergic pathways. However, motor changes that are induced by unilateral 6-OHDA injections may …

br, pe (code pays fourni par la source)