Andong Shao

Detection of tumor immunity-related ENPP1 using AIE-active probe QM-AMP

Yuwei Wang, Ting Yang, Shichang Liu, Haojian Yang et autres

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), a crucial biomarker on the surface of tumor cells, plays a significant role in immune suppression and cancer metastasis. In this study, we successfully developed a novel amphiphilic fluorescent probe, QM-AMP, based on quinoline-malononitrile aggregation-induced emission (AIE) characteristics, …

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Mapping Dynamic Protein Clustering with AIEgen‐Active Chemigenetic Probe

Chenxu Yan, Wendi Zhu, Runqi Li, Qin Xu et autres

Abstract Protein clustering/disassembling is a fundamental process in biomolecular condensates, playing a crucial role in cell fate decision and cellular homeostasis. However, the inherent features of protein clustering, especially for its reversible behavior and subtle microenvironment variation, present significant hurdles in probe …

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Abstract 4491: Development of IRE-1 inhibitors for B cell cancer therapy

Andong Shao, Chih-Hang Anthony Tang, Juan R. Del Valle, Chih‐Chi Andrew Hu

Abstract In response to the endoplasmic reticulum (ER) stress, the IRE-1 kinase/RNase splices the mRNA of the XBP-1 gene, resulting in the spliced XBP-1 (XBP-1s) mRNA that encodes the functional XBP-1s transcription factor. XBP-1s is critically important for the growth and survival …

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Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

Lulu Siang-Ru Huang, Tongyi Zhao, Weijun Zhao, Andong Shao et autres

Herpes zoster remains an important global health issue and mainly occurs in aged and immunocompromised individuals with an early exposure history to Varicella Zoster Virus (VZV). Although the licensed vaccine Shingrix has remarkably high efficacy, undesired reactogenicity and increasing global demand causing …

cn, se (code pays fourni par la source)

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

Lulu Huang, Tongyi Zhao, Weijun Zhao, Andong Shao et autres

Abstract Herpes zoster remains an important global health issue and mainly occurs in aged and immunocompromised individuals with an early exposure history to Varicella Zoster Virus (VZV). Although the licensed vaccine Shingrix has a remarkably high efficacy, undesired reactogenicity and increasing global …

cn, se (code pays fourni par la source)

Supplementary Data from Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy

Andong Shao, Qin Lan Xu, Walker T. Spalek, Christopher F. Cain et autres

Supplementary methods, table, figures and legends

Data from Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy

Andong Shao, Qin Lan Xu, Walker T. Spalek, Christopher F. Cain et autres

Abstract The IRE-1 kinase/RNase splices the mRNA of the XBP-1 gene, resulting in the spliced XBP-1 (XBP-1s) mRNA that encodes the functional XBP-1s transcription factor that is critically important for the growth and survival of B-cell leukemia, lymphoma, and multiple myeloma (MM). …

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Supplementary Data from Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy

Andong Shao, Qin Lan Xu, Walker T. Spalek, Christopher F. Cain et autres

Supplementary methods, table, figures and legends

Data from Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy

Andong Shao, Qin Lan Xu, Walker T. Spalek, Christopher F. Cain et autres

Abstract The IRE-1 kinase/RNase splices the mRNA of the XBP-1 gene, resulting in the spliced XBP-1 (XBP-1s) mRNA that encodes the functional XBP-1s transcription factor that is critically important for the growth and survival of B-cell leukemia, lymphoma, and multiple myeloma (MM). …

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A study on optical properties of various hot drug molecules by 2020

Chun Zhang, Yuting Yang, Xue Yan, Yitao Sun et autres

The optical properties of two small drug molecules (18 and 134) among top 200 pharmaceuticals by retails in 2020 have been systematically studied with a synergy of simulation and experiment.

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Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy

Andong Shao, Qin Song Xu, Walker T. Spalek, Christopher F. Cain et autres

Abstract The IRE-1 kinase/RNase splices the mRNA of the XBP-1 gene, resulting in the spliced XBP-1 (XBP-1s) mRNA that encodes the functional XBP-1s transcription factor that is critically important for the growth and survival of B-cell leukemia, lymphoma, and multiple myeloma (MM). …

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STING regulates BCR signaling in normal and malignant B cells

Chih-Hang Anthony Tang, Avery C. Lee, Shiun Chang, Qin Song Xu et autres

Abstract STING is an endoplasmic reticulum (ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type I interferons; however, the role of STING in B cell receptor (BCR) signaling remains unclear. We generated STING V154M knock-in mice and showed …

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